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  4. PTPN9 Antibody, Biotin conjugated

PTPN9 Antibody, Biotin conjugated

  • 中文名稱：
    PTPN9兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA019045LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PTPN9 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PTPN9
  • 別名：
    MEG2 antibody; non-receptor type 9 antibody; protein tyrosine phosphatase antibody; Protein tyrosine phosphatase MEG2 antibody; Protein-tyrosine phosphatase MEG2 antibody; PTN9_HUMAN antibody; PTPase MEG2 antibody; Ptpn9 antibody; Tyrosine protein phosphatase non receptor type 9 antibody; Tyrosine-protein phosphatase non-receptor type 9 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Tyrosine-protein phosphatase non-receptor type 9 protein (221-339AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.
  • 基因功能參考文獻(xiàn)：
    1. Results from a study on gene expression variability markers in early-stage human embryos shows that PTPN9 is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    2. this study highlights an important role for miR-96 in the regulation of PTPN9 in breast cancer cells and may provide insight into the molecular mechanisms of breast carcinogenesis. PMID: 27857177
    3. Expression of MEG2 is reversely correlated with that of miR-181a-5p in gastric cancer. PMID: 28747184
    4. PTPN9 inhibited cell proliferation in HepG2 cells. PMID: 26715439
    5. PTPMeg2 is an important phosphatase for the dephosphorylation of STAT3 and plays a critical role in breast cancer development. PMID: 22394684
    6. This study indentified VEGFR2 as a PTPN9 substrate, and indicated that PTPN9 is a negative regulator of VEGFR2 signaling and function in endothelial cells. PMID: 22763125
    7. data suggest PTPN9 as a negative regulator of breast cancer cells by targeting ErbB2 and EGFR and inhibiting STAT activation PMID: 20335174
    8. Purification and characterization of protein tyrosine phosphatase PTP-MEG2 PMID: 12112018
    9. PTP-MEG2 has an important role in the development of erythroid cells. PMID: 12920026
    10. PTPase-MEG2 through its Sec14p homology domain couples inositide phosphorylation to tyrosine dephosphorylation and the regulation of intracellular traffic of the secretory pathway in T cells. PMID: 14662869
    11. PTP-MEG2 reduced the phosphotyrosine content of NSF and co-localized with NSF and syntaxin 6 in intact cells, the first demonstrated role for a protein tyrosine phosphatase in the regulated secretory pathway PMID: 15322554
    12. role in the negative regulation of hepatic insulin signaling PMID: 16679294
    13. the N terminus of PTPMEG2 is necessary for the targeting of this phosphatase to the secretory vesicle compartment by association with other proteins involved in intracellular transport. PMID: 17387180

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  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class 3 subfamily
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 9661

    OMIM: 600768

    KEGG: hsa:5780

    STRING: 9606.ENSP00000303554

    UniGene: Hs.445775