PVRL3 Antibody
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中文名稱:PVRL3兔多克隆抗體
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貨號:CSB-PA005242
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規(guī)格:¥880
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圖片:
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:
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別名:CD113 antibody; CDw113 antibody; DKFZP566B0846 antibody; FLJ90624 antibody; Nectin-3 antibody; Nectin3 antibody; Poliovirus receptor related 3 antibody; Poliovirus receptor related protein 3 antibody; Poliovirus receptor-like 3 antibody; Poliovirus receptor-related protein 3 antibody; PPR3 antibody; PRR3 antibody; Pvrl3 antibody; PVRL3_HUMAN antibody; PVRR3 antibody
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宿主:Rabbit
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反應(yīng)種屬:Human,Mouse,Rat
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免疫原:Synthesized peptide derived from the Internal region of Human Nectin 3.
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
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抗體亞型:IgG
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純化方式:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:WB, ELISA
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推薦稀釋比:
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:20000 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.
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基因功能參考文獻(xiàn):
- Nectin-3 mutation in men with severe teratospermia PMID: 28689229
- Data suggest that 3 independent regions of TcdB (Clostridium difficile toxin B; 1372-1493, 1493-1848, 1851-2366) contribute to binding and entry of TcdB into mammalian cells; residues 1372-1493 are sufficient for interaction with PVRL3. PMID: 26602083
- Expression of nectin-3 in pancreatic cancer can be a prognostic factor. PMID: 25690753
- PVRL3 is a physiologically relevant binding partner that can serve as a target for the prevention of TcdB-induced cytotoxicity in C. difficile infection. PMID: 26038560
- Nectin-3 is associated with the formation of cell junctions and be a putative suppressor molecule to the invasion of breast cancer cells. PMID: 24386110
- Nectin-3 trans-interacts with Nectin-2 to promote lymphocyte and monocyte extravasation. PMID: 24116228
- Data suggest that expression of nectin-3 is up-regulated in eutopic endometrium of patients with endometriosis as compared with control subjects and up-regulated in all endometriotic lesions investigated compared with eutopic endometrium. PMID: 22926846
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亞細(xì)胞定位:Cell membrane; Single-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane.
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蛋白家族:Nectin family
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組織特異性:Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.
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數(shù)據(jù)庫鏈接:
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