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Phospho-FANCG (Ser383) Antibody

  • 中文名稱：
    磷酸化-FANCG (Ser383)兔多克隆抗體
  • 貨號(hào)：
    CSB-PA972302
  • 規(guī)格：
    ￥2454
  • 圖片：
    • Western blot analysis of extracts from K562 cells, using FANCG (Phospho-Ser383) antibody. The lane on the right is treated with the synthesized peptide.
    • Western blot analysis of extracts from cos-7 cells (Lane 2), using FANCG (Phospho-Ser383) Antibody. The lane on the left is treated with synthesized peptide
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) FANCG Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    FANCG
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Peptide sequence around phosphorylation site of serine 383 (R-F-S(p)-P-P) derived from Human FANCG.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.
  • 基因功能參考文獻(xiàn)：
    1. LOH may predominantly indicate copy number gains in FANCF and losses in FANCG and BRIP1. Integration of copy number data and gene expression proved difficult as the available sample sets did not overlap. PMID: 28440438
    2. studied the impact of mutations on the function and structure of FANCG PMID: 28024295
    3. a systems biology approach for elucidating the therapeutic potential of curcumin against FA and leukemia is investigated by analyzing the computational molecular interactions of curcumin ligand with FANC G of FA and seven other key disease targets of leukemia PMID: 27608133
    4. Patients, homozygous for the FANCG founder mutation, present with severe cytopenia but progress to bone marrow failure at similar ages to other individuals affected with Fanconi anemia of heterogeneous genotype. PMID: 25477267
    5. founder haplotype analysis of FANCG for the Korean Fanconi anemia population PMID: 25703136
    6. A new role of FANCG in Homologous recombination repair of interstrand crosslinks through K63Ub-mediated interaction with the Rap80-BRCA1 complex. PMID: 25132264
    7. Three novel single base pair deletions, resulting in frameshift mutations (c.247delA, c.179delT and c.899delT) were identified in patients with Fanconi anaemia PMID: 24300640
    8. Areca nut extracts-induced miR-23a was correlated with a reduced FANCG expression and DSB repair, which might contribute to ANE-associated human malignancies. PMID: 21750350
    9. Study of the molecular evolution of FA genes using database search methods such as PSI-BLAST suggested that FANCG may contain a known domain, and that this protein is a member of the family of tetratricopeptide repeat-containing proteins. PMID: 12432219
    10. There is remarkably lage sequence variation in FANCG gene mutations and polymorphisms across ethnic and racial backgrounds found in the International Fanconi Anemia Registry they include IVS8-2A>G, IVS11+1G>c, 1794_1803del10, and IVS3+1G>C. PMID: 12552564
    11. FANCG was able to mediate interaction between FANCA and FANCF, as well as between monomers of FANCA PMID: 12649160
    12. FANCG is required for efficient homologous recombination-mediated repair of at least some types of DNA double-strand breaks PMID: 12861027
    13. FANCG interacts directly with BRCA2. PMID: 12915460
    14. A unique Fanconi-anemia-causing mutation, FANCG splice-site mutation IVS4+3A>G, showed exon 4 skipping. PMID: 15059067
    15. Primary fibroblasts from patients with Fanconi anemia with reduced FANCG expression show no signs of telomere dysfunction. PMID: 15319283
    16. FANCG, in addition to stabilising the FA core complex, may have a role in building multiprotein complexes that facilitate homologous recombination repair. PMID: 16621732
    17. Four human FANCG polymorphic variants show normal biological function. PMID: 17010390

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  • 相關(guān)疾病：
    Fanconi anemia complementation group G (FANCG)
  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm. Note=The major form is nuclear. The minor form is cytoplasmic.
  • 組織特異性：
    Highly expressed in testis and thymus. Found in lymphoblasts.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 3588

    OMIM: 602956

    KEGG: hsa:2189

    STRING: 9606.ENSP00000367910

    UniGene: Hs.591084