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  4. Phospho-FOSB (S27) Antibody

Phospho-FOSB (S27) Antibody

  • 中文名稱：
    磷酸化-FOSB (S27)兔多克隆抗體
  • 貨號：
    CSB-PA008387
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Activator protein 1 antibody; AP 1 antibody; DKFZp686C0818 antibody; FBJ murine osteosarcoma viral oncogene homolog B antibody; fosB antibody; FOSB_HUMAN antibody; G0/G1 switch regulatory protein 3 antibody; G0S3 antibody; GOS 3 antibody; GOS B antibody; GOS3 antibody; GOSB antibody; MGC42291 antibody; Oncogene FOS B antibody; Oncogene FOSB antibody; Protein fos B antibody; Protein fosB antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from Human Fos B around the phosphorylation site of S27.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    FosB interacts with Jun proteins enhancing their DNA binding activity.
  • 基因功能參考文獻(xiàn)：
    1. miR-144-3p plays an important role in pancreatic cancer cell proliferation, migration, and invasion by targeting FOSB PMID: 28653602
    2. FOSB immunohistochemistry is sensitive in the diagnosis of angiolymphoid hyperplasia with eosinophilia, and allows differentiation from its histological mimics PMID: 29527734
    3. FOSB overexpression results in TNBC cell death, whereas inhibition of calcium signaling eliminates FOSB induction and blocks TP4-induced TNBC cell death PMID: 27248170
    4. results shows the involvement of Spry2 in regulation of FosB and Runx2 genes, MAPK signaling and proliferation of mesenchymal stem cells. PMID: 28387432
    5. the mechanism underlying redox-regulation of AP-1 Fos/Jun transcription factors and provide structural insight for therapeutic interventions targeting AP-1 proteins. PMID: 28981703
    6. The NFATc3 first induced the expression of its interaction partner FosB before forming the heterodimeric NFATc3-FosB transcription factor complex, which bound the proximal AP-1 site in the TF gene promoter and activated TF expression. PMID: 28724635
    7. FosB expression in the prefrontal cortex and hippocampus of the cocaine addicted and depression patients PMID: 27494187
    8. FOSB is a highly sensitive and diagnostically useful marker for pseudomyogenic hemangioendothelioma. PMID: 28009608
    9. our findings show that DeltaFosB increases the expression of MMP-9 and exhibits a significantly high survival and proliferation in MCF-7 cells. PMID: 26608367
    10. Diffuse and strong FOSB expression was specific for pseudomyogenic hemangioendothelioma in the current series and FOSB immunohistochemistry is an effective tool for differentiating between PHE and its histological mimics. PMID: 27515856
    11. Our results using a number of approaches, such as promoter reporter assay, FosB knock down and Chip assay, suggest that the expression of miR-22 is regulated transcriptionally by FosB. PMID: 27889568
    12. These results suggest that SETDB1- mediated FosB expression is a common molecular phenomenon, and might be a novel pathway responsible for the increase in cell proliferation that frequently occurs during anticancer drug therapy. PMID: 26949019
    13. studies of FosB are providing new insight into the molecular basis of depression and antidepressant action. PMID: 25446562
    14. The abnormalities were screened by FISH in 44 epithelioid hemangioma (EH) from different locations with seven additional EH revealing FOSB gene rearrangements, all except one being fused to ZFP36. PMID: 25043949
    15. This study describing the expres-sion pattern of FosB/ FosB immunoreactivity inpost mortem basal ganglia sections from Parkinson disease patients. PMID: 23933656
    16. Pseudomyogenic haemangioendothelioma consistently displays a SERPINE1-FOSB fusion gene, resulting from a translocation between chromosomes 7 and 19. PMID: 24374978
    17. Data indicate a significant correlation in miR-181b, FOS and miR-21 expression glioma tissues. PMID: 23810250
    18. Report Fos-B expression in skin keratinocytes/fibroblasts and keloid fibroblasts exposed to genistein. PMID: 23614275
    19. AP-1 protein induction during monopoiesis favors C/EBP: AP-1 heterodimers over C/EBP homodimerization and stimulates FosB transcription. PMID: 21543584
    20. Induction of a DeltaFOSB mediated transcriptional pattern in the prefrontal cortex is opposite to the down-regulation observed in the nucleus accumbens in patients with major depressive disorder PMID: 21616539
    21. Findings indicate that neurobehavioral stress leads to FosB-driven increases in IL8, which is associated with increased tumor growth and metastases. PMID: 20826776
    22. transcription factor FosB/activating protein-1 (AP-1) activation is a prominent downstream signal of the extracellular nucleotide receptor P2RX7 in monocytic and osteoblastic cells PMID: 20813842
    23. RGS16 and FosB are underexpressed in pancreatic cancer with lymph node metastasis and associated with reduced survival PMID: 20571966
    24. demonstrated that a functional AP-1 site mediates MMP-2 transcription in cardiac cells through the binding of distinctive Fra1-JunB and FosB-JunB heterodimers. The synthesis of MMP-2 is considered to be independent of the AP-1 transcriptional complex PMID: 12371906
    25. AP-1 (c-Jun & FosB) binds to a site in the 5' untranslated region of the CD95L gene. Transdominant negative Jun mutants reduce CD95L promoter activity. FosB dimerized with c-Jun has an important role in TCR/CD3-mediated activation-induced cell death. PMID: 12618758
    26. In hepatoma-associated anorexia-cachexia FpsB was induced in several brain areas of thes forebrain. PMID: 15926923
    27. activation of protein kinase A elicits an immediate response through induction of genes such as ID2 and FosB, followed by sustained secretion of bone-related cytokines such as BMP-2, IGF-1, and IL-11 PMID: 18490653
    28. DeltaFosB was able to trigger partial Pref-1-mediated de-differentiation of adipocytes, which also retained their adipocytic cell phenotype. PMID: 18491952
    29. An IFN-gamma-mediated homeostatic loop limits the potential for tissue damage associated with inflammation and identifies transcriptional factor AP-1 that regulates matrix metalloproteinase expression in myeloid cells in inflammatory settings. PMID: 18802113
    30. MicroRNA-101, which is aberrantly expressed in hepatocellular carcinoma, could repress the expression of the FOS oncogene. PMID: 19133651
    31. FosB is induced in PMA treated K562 cells in a sustained manner and forms an active AP-1 protein-DNA complex. Down-regulation of FosB with specific shRNAs inhibited the induction of CD41, a specific cell surface marker of megakaryocytes. PMID: 19381435
    32. Results suggest that in addition to clinically prognostic factors, FOS-B expression has a debatable impact on patient survival. PMID: 19795327

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    BZIP family, Fos subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3797

    OMIM: 164772

    KEGG: hsa:2354

    STRING: 9606.ENSP00000245919

    UniGene: Hs.590958