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  4. Phospho-IL9R (S519) Antibody

Phospho-IL9R (S519) Antibody

  • 中文名稱：
    磷酸化-IL9R (S519)兔多克隆抗體
  • 貨號：
    CSB-PA009570
  • 規(guī)格：
    ￥880
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    CD129 antibody; IL-9 receptor antibody; IL-9R antibody; Il9r antibody; IL9R_HUMAN antibody; IL9RX antibody; IL9RY antibody; Interleukin 9 receptor antibody; Interleukin-9 receptor antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from Human IL-9R around the phosphorylation site of S519.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產品評價

靶點詳情

  • 功能：
    This is a receptor for interleukin-9.
  • 基因功能參考文獻：
    1. Results show that silencing of the IL-9R gene alleviates the drug resistance of diffuse large B-cell lymphoma (DLBCL) cell lines that is induced by IL-9 suggesting that IL-9R is involved in chemotherapy drug resistance of DLBCL. PMID: 27364124
    2. The findings indicated that IL-9R was constitutively expressed and exerted a tumor-promoting effect in hepatocellular carcinoma, whose expression level may be a useful biomarker of tumor invasiveness and patient clinical outcome. PMID: 26082242
    3. Low expression of CD39(+) /CD45RA(+) on regulatory T cells (Treg ) cells in type 1 diabetic children in contrast to high expression of CD101(+) /CD129(+) on Treg cells in children with coeliac disease. PMID: 25421756
    4. Mice with PU.1 deficiency in T cells were protected from colitis, whereas treatment with antibody to IL-9 suppressed colitis PMID: 24908389
    5. Our findings suggest that overexpression of IL-9R may contribute to the pathogenesis of diffuse large B-cell lymphoma PMID: 23638223
    6. One of the identified peptide sequences corresponded to a fragment of the human interleukin-9 receptor alpha (IL-9Ralpha). PMID: 22638550
    7. There is an association of at least 2 X-chromosomal genes with rheumatoid arthritis: TIMP1 and IL9R. PMID: 19723899
    8. Human bronchial epithelium expresses interleukin-9 receptors. PMID: 11868823
    9. variations in the IL9R gene may influence susceptibility to childhood wheezing and atopy, and data support the notion that different haplotypes may have sex specific influences PMID: 15591265
    10. IL-9R alpha was expressed on human tonsillar B cells, with an ability to transduce signals through activation of signal transducer and activator of transcription 3 and 5. PMID: 17919707
    11. These results reveal a regulatory function for IFN-gamma and IL-10 on modulating the inducible IL-9Ralpha expression levels on peripheral blood neutrophils by T(H)2 cytokines. PMID: 19401191

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Secreted.
  • 蛋白家族：
    Type I cytokine receptor family, Type 4 subfamily
  • 數(shù)據庫鏈接：

    HGNC: 6030

    OMIM: 300007

    KEGG: hsa:3581

    STRING: 9606.ENSP00000244174

    UniGene: Hs.406228