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  4. Phospho-PLCG1 (Tyr783) Antibody

Phospho-PLCG1 (Tyr783) Antibody

  • 中文名稱：
    磷酸化-PLCG1 (Tyr783)兔多克隆抗體
  • 貨號：
    CSB-PA910323
  • 規(guī)格：
    ￥2454
  • 圖片：
    • Western blot analysis of extracts from HL60 cells untreated or treated with EGF using PLCg1(Phospho-Tyr783) Antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PLCG1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Peptide sequence around phosphorylation site of tyrosine 783 (G-F-Y(p)-V-E) derived from Human PLCG1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
  • 基因功能參考文獻(xiàn)：
    1. Data suggest that FGFR3 with mutation found in SADDAN (but not FGFR3 with mutation found in TDII) affects cytoskeleton organization in chondrocytes by inducing tyrosine hyperphosphorylation of paxillin; binding of FGFR3 to PLCG1 appears to be involved. (FGFR3 = fibroblast growth factor receptor 3; SADDAN = Severe Achondroplasia with Developmental Delay and Acanthosis Nigricans; TDII = Thanatophoric Dysplasia type II) PMID: 29242050
    2. PLCgamma2 plays a critical role for Ca(2+) Flux in HCECs stimulated by A. fumigatus hyphae. Syk acts upstream of PLCgamma2 in the Dectin-1 signaling pathway. PMID: 30005593
    3. a previously unappreciated role for PLC-gamma1 in the positive regulation of Zap-70 and T-cell receptor tyrosine phosphorylation. Conversely, PLC-gamma1 negatively regulated the phosphorylation of SLP-76-associated proteins, including previously established Lck substrate phosphorylation sites within this complex. PMID: 28644030
    4. Syk-induced signals in bone marrow stromal cell lines are mediated by phospholipase C gamma1 (PLCgamma1) in osteogenesis and PLCgamma2 in adipogenesis. PMID: 28786489
    5. PLCG1, along with ITGA4 are regulated by miR-30b in clinical samples of coronary artery cells from coronary atherosclerosis patients. PMID: 27464494
    6. the central biological role of the novel IL-2-R/Lck/PLCgamma/PKCtheta;/alphaPIX/Rac1/PYGM signalling pathway is directly related to the control of fundamental cellular processes such as T cell migration and proliferation. PMID: 27519475
    7. LAT and phospholipase C-gamma dephosphorylation by SHP-1 inhibits natural killer cell cytototoxicity PMID: 27221712
    8. The products of PLC-gamma activity mediate the innate immune response by regulating respiratory burst, phagocytosis, cell adhesion, and cell migration. (Review) PMID: 27707630
    9. 1,25(OH)2D3 indirectly modulates the differentiation of Treg/Th17 cells by a ff ;ecting the VDR/PLC-gamma1/TGF-beta1pathway. These results indicate that administration 1,25(OH)2D3 supplements may be a beneficial treatment for organ transplantation recipients. PMID: 28926770
    10. Results show that PLCgamma-1 activation enhanced skin cell transformation. PMID: 28574619
    11. These results suggest that immobilized EGF increases collective keratinocyte displacement via an increase in single-cell migration persistence resulting from altered EGFR trafficking and PLCgamma1 activation. PMID: 27025961
    12. High FLC gamma expression is associated with Radioresistance in Glioblastoma. PMID: 26896280
    13. High PLC gamma expression is associated with breast cancer. PMID: 28112359
    14. We show that the decrease in PI(4,5)P2 level under non-stimulated conditions inhibits PTEN activity leading to the aberrant activation of the oncoprotein Akt. As well as defining a novel mechanism of Akt phosphorylation with important therapeutic consequences, we also demonstrate that differential expression levels of FGFR2, Plc11 and Grb2 correlate with patient survival PMID: 26212011
    15. the PLCgamma-1 signaling plays an important role in the H1N1-induced inflammatory responses. Our study suggests that targeting the PLCgamma-1 signaling is a potential antiviral therapy against H1N1 by inhibiting both viral replication and excessive inflammation. PMID: 27310357
    16. These results indicate that PP1 is recruited to the extracellular calcium-dependent E-cadherin-catenin-PIP5K1a complex in the plasma membrane to activate PIP5K1a, which is required for PLC-g1 activation leading to keratinocyte differentiation. PMID: 27340655
    17. FGFR1 dimers forms a complex with its effector PLCgamma1. PMID: 26482290
    18. High PLC gamma1 expression is associated with gastric adenocarcinoma. PMID: 26811493
    19. Report PLCG1 genetic alterations in angiosarcomas. PMID: 26735859
    20. expression of PLC-gamma1 and PIKE positively correlated with the tumor differentiation of oral squamous cell carcinoma. PMID: 26464646
    21. In a transgenic mouse model, PLCgamma1 is the dominant signaling effector by which activation of TrkB promotes epilepsy. PMID: 26481038
    22. hsa-miR-665 and hsa-miR-95 were downregulated in GSRCC but upregulated in intestinal gastric adenocarcinoma, and the relatively differential expression of the miRNAs negatively controlling their target genes, GLI2 and PLCG1 PMID: 25964059
    23. Results provide evidence that PTPRB and PLCG1 mutations are driving events in a subset of secondary angiosarcomas. PMID: 24795022
    24. PLLG1 protein mutations are uncommon in cutaneous T-cell lymphomas. PMID: 25910029
    25. PLCgamma1 is part of the molecular mechanism. PMID: 25491205
    26. Recurrent presence of the PLCG1 S345F mutation is associated with nodal peripheral T-cell lymphomas. PMID: 25304611
    27. The degradation of zonula occludens-1 (ZO-1), and claudin-2 exhibited a great dependence on the activation of the transient receptor potential melastatin (TRPM) 2 channel, phospholipase Cgamma1 (PLCgamma1) and the protein kinase Calpha (PKCalpha) signaling cascade. PMID: 23629676
    28. Data from structural, genetic, and mechanistic studies on the role of PLCG1 in cell biology suggest that dysfunctional forms of PLCG1 are linked to immune disorders and cancer. [REVIEW] PMID: 25456276
    29. This SOCS7 knockdown-attributed effect could be due to a precise anti-PLCg-1 role. PMID: 25162020
    30. The activation of the gamma1 isoform of phospholipase C (PLCgamma1) is critical for pressure sensing in cerebral arteries and subsequent vasoconstriction. PMID: 24866019
    31. these findings indicate that the PLCgamma1-R707Q mutation causes constitutive activation of PLCgamma1 and may represent an alternative way of activation of KDR/PLCg1 signaling besides KDR activation in angiosarcomas PMID: 25252913
    32. Results reveal that PLCG1 is genetically altered in a significant portion of Cutaneous T-cell lymphomas. PMID: 24706664
    33. A portion of PLC-gamma1 phosphorylated on tyrosine 783 is not found at LAT-containing clusters but instead is located at TCR-containing clusters. PMID: 24412752
    34. Extracellular K(+) concentration regulated the levels of activated PLC-gamma1, chromosome X, and carbachol-stimulated intracellular Ca(2+) mobilization in human endothelial cells PMID: 24785188
    35. Increased proliferative and survival mechanisms in cutaneous T-cell lymphoma may partially depend on the acquisition of somatic mutations in PLCG1 and other genes that are essential for normal T-cell differentiation. PMID: 24497536
    36. PLCG1, a signal transducer of tyrosine kinases, encoded a recurrent, likely activating p.Arg707Gln missense variant in 3 of 34 cases of angiosarcoma. PMID: 24633157
    37. Phospholipase C gamma1 plays a key role in cell migration and invasion. [review] PMID: 23925006
    38. PLCgamma1 signaling is the dominant pathway in promoting limbic epileptogenesis. PMID: 24502564
    39. Metastatic outcome can be dictated by the constitutive competition between Grb2 and Plcgamma1 for the phosphorylation-independent binding site on FGFR2. PMID: 24440983
    40. study showed that PLC-gamma directly binds c-Src through its SH2 domains, and this interaction is necessary for carbachol mediated inhibition of NHE3 activity in Caco-2/BBe/NHE3 cells PMID: 23703528
    41. PLC-gamma1 is highly expressed in brain and participates in neuronal cell functions mediated by neurotrophins. (Review) PMID: 23063587
    42. High expression of PLCgamma1, and of its activated forms, is associated with a worse clinical outcome. PMID: 22847294
    43. The role of four domains of human PLCG1 defined by structural and biochemical investigation. PMID: 23063561
    44. Data indicate that Akt expression was up-regulated with high glucose and insulin in both cell lines, whereas PLCgamma expression was enhanced in colon cancer cells only. PMID: 22554284
    45. analysis of two distinct mechanisms by which phospholipase C-gamma1 mediates epidermal growth factor-induced keratinocyte migration and proliferation PMID: 22749651
    46. T cell receptor (TCR)-mediated proliferation is impaired in PLCgamma1/PLCgamma2 double-deficient T cells compared with PLCgamma1 single-deficient T cells. PMID: 22837484
    47. The oncogenic truncation of this region elicits conformational changes that interfere with the Vav1-mediated activation of PLCgamma1 and that inhibit calcium mobilization. PMID: 22474331
    48. Report the interplay of HER2/HER3/PI3K and EGFR/HER2/PLC-gamma1 signalling in breast cancer cell migration and dissemination. PMID: 22262199
    49. Translocation of PLC-gamma 1 to the cell membrane and the associated calcium signal were enhanced only in mast cells responding to EP3 prostaglandin E2 receptor agonist sulprostone. PMID: 21798286
    50. our approach, which is applicable to any set of interval scale traits that is heritable and exhibits evidence of phenotypic clustering, identified three new loci in or near APOC1, BRAP, and PLCG1, which were associated with multiple phenotype domains. PMID: 22022282

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  • 亞細(xì)胞定位：
    Cell projection, lamellipodium. Cell projection, ruffle.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9065

    OMIM: 172420

    KEGG: hsa:5335

    STRING: 9606.ENSP00000244007

    UniGene: Hs.268177