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Pka-C1 Antibody, Biotin conjugated

  • 中文名稱：
    Pka-C1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA318954LD01DLU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Drosophila melanogaster Pka-C1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    Pka-C1
  • 別名：
    Pka-C1 antibody; CdkA antibody; DC0 antibody; CG4379 antibody; cAMP-dependent protein kinase catalytic subunit 1 antibody; PKA C antibody; EC 2.7.11.11 antibody; Protein kinase DC0 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Drosophila melanogaster
  • 免疫原：
    Recombinant Drosophila melanogaster cAMP-dependent protein kinase catalytic subunit 1 protein (2-353AA)
  • 免疫原種屬：
    Drosophila melanogaster
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Serine/threonine-protein kinase involved in memory formation. Promotes long-term memory by phosphorylating meng and by regulating CrebB protein stability and activity. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology when anchored to the membrane.
  • 基因功能參考文獻(xiàn)：
    1. Hedgehog signalling activation causes PKA to switch its substrates from Ci to Smo within the Hh signalling complex. PMID: 25289679
    2. tightly controlled dose-dependent intra-neuronal PKA activity levels are critical in determining the dendritic arbor complexity, one of the possible ways being through the regulation of organelle distribution. PMID: 25017992
    3. Alpha- NAC is a substrate of PKA following Parathyroid Hormone signaling. PMID: 24550008
    4. that manipulations that increase cAMP/PKA signaling in adipokinetic hormone (AKH)-producing cells at the base of the neuroendocrine ring gland restore the dNf1 growth deficiency. PMID: 24278035
    5. Acute expression of protein kinase A inhibitory peptide in aged animals is sufficient to reverse age-related memory impairment in wild-type animals. PMID: 21084612
    6. Two-dimensional gel electrophoresis, (32)P labelling and immunodetection show that "in vitro" PKA phosphorylates the serine in the C-terminus of the NDUFS4 subunit in isolated bovine complex I. PMID: 20433953
    7. Its signaling underlies age-related memory impairment.(review) PMID: 18646611
    8. We found that decreased PKA activity in neurons rendered flies insensitive to the wake-promoting effects of octopamine. PMID: 18799671

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  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, cAMP subfamily
  • 組織特異性：
    More abundant in adult head than adult body.
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: dme:Dmel_CG4379

    STRING: 7227.FBpp0079448

    UniGene: Dm.2136