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RAB38 Antibody

  • 中文名稱：
    RAB38兔多克隆抗體
  • 貨號：
    CSB-PA019191LA01HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時一口價
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RAB38 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RAB38
  • 別名：
    Antigen NY MEL 1 antibody; Melanoma antigen NY MEL 1 antibody; Melanoma antigen NY-MEL-1 antibody; NY MEL 1 antibody; RAB 38 antibody; Rab related GTP binding protein antibody; Rab38 antibody; RAB38 member RAS oncogene family antibody; RAB38_HUMAN antibody; Ras related protein Rab 38 antibody; Ras-related protein Rab-38 antibody; rrGTPbp antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ras-related protein Rab-38 protein (1-211AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，RAB38 Antibody (CSB-PA019191LA01HU)，的標記方式是Non-conjugated。對于RAB38 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA019191LB01HU RAB38 Antibody, HRP conjugated ELISA
    FITC CSB-PA019191LC01HU RAB38 Antibody, FITC conjugated
    Biotin CSB-PA019191LD01HU RAB38 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產品評價

靶點詳情

  • 功能：
    May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes.
  • 基因功能參考文獻：
    1. Rab38 was associated with albuminuria in type 2 diabetes patients. Relative expression of RAB38 was higher in tubuli of patients with diabetic kidney disease compared with control subjects. PMID: 26631737
    2. MiR-124 significantly decreases the H2O2-induced apoptosis of human hepatic L02 cells by targeting the Rab38 gene and activating the AKT pathway. PMID: 24875359
    3. The expression levels of RAB38 were significantly associated with grade progression as well as prognosis in gliomas. RAB38 is an important prognostic biomarker and potential therapeutic target in gliomas. PMID: 24026199
    4. Studies confirmed elevated expression of three target antigens RAB38, TBCE, and DUSP12 in CML. PMID: 20103624
    5. Not a new major locus for Japanese oculocutaneous albinisms. PMID: 12850305
    6. Varp physically interacts with Rab38, and preferentially binds to the active GTP-bound form of Rab38 both in vitro and in vivo. PMID: 18477474

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  • 亞細胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Melanosome membrane.
  • 蛋白家族：
    Small GTPase superfamily, Rab family
  • 組織特異性：
    Expressed in melanocytes.
  • 數據庫鏈接：

    HGNC: 9776

    OMIM: 606281

    KEGG: hsa:23682

    STRING: 9606.ENSP00000243662

    UniGene: Hs.591975