RAPGEF1 Antibody, FITC conjugated
-
中文名稱:RAPGEF1兔多克隆抗體, FITC偶聯(lián)
-
貨號(hào):CSB-PA613430NC01HU
-
規(guī)格:¥880
-
其他:
產(chǎn)品詳情
-
產(chǎn)品名稱:Rabbit anti-Homo sapiens (Human) RAPGEF1 Polyclonal antibody
-
Uniprot No.:
-
基因名:
-
別名:C3G antibody; C3G protein antibody; CRK SH3 binding GNRP antibody; CRK SH3-binding GNRP antibody; DKFZp781P1719 antibody; GRF 2 antibody; GRF2 antibody; Guanine nucleotide releasing factor 2 (specific for crk proto oncogene) antibody; Guanine nucleotide releasing factor 2 antibody; Guanine nucleotide-releasing factor 2 antibody; OTTHUMP00000064558 antibody; Protein C3G antibody; Rap guanine nucleotide exchange factor (GEF) 1 antibody; Rap guanine nucleotide exchange factor 1 antibody; RAPGEF 1 antibody; RAPGEF1 antibody; RPGF1_HUMAN antibody
-
宿主:Rabbit
-
反應(yīng)種屬:Human
-
免疫原:Peptide sequence from Human Rap guanine nucleotide exchange factor 1 protein (22-40AA)
-
免疫原種屬:Homo sapiens (Human)
-
標(biāo)記方式:FITC
-
克隆類型:Polyclonal
-
抗體亞型:IgG
-
純化方式:>95%, Protein G purified
-
濃度:It differs from different batches. Please contact us to confirm it.
-
保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式:Liquid
-
儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
-
功能:Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth.
-
基因功能參考文獻(xiàn):
- our studies uncover novel mechanisms by which C3G controls key aspects of tumorigenesis. PMID: 27286263
- C3G/RAP1 activity is involved in the metastatic spread of epithelial ovarian cancer. PMID: 25617801
- C3G plays an important role in platelet clotting through a mechanism involving its GEF activity and suggest that it might be also involved in neutrophil development. PMID: 22659131
- The possibility of cellular phospho-C3G (pC3G) being a substrate of the intracellular T-cell protein tyrosine phosphatase TC-PTP (PTPN2) using the human neuroblastoma cell line, was studied. PMID: 21876762
- Lyn controls spatial activation of Rap1 by recruiting the CrkL-C3G protein complex to the leading edge PMID: 21628423
- found somatic demethylation of a relaxed-criterion CpG island (CGI-B) located in the first intron of RAPGEF1 in 40% of colon cancers and 8% of gastric cancers relative to their matching normal tissues that were always methylated PMID: 21399874
- Data demonstrated that the polymorphism in TP53 (rs1042522) was associated with type 2 diabetes, and that potential interaction of TP53 (rs1042522) and RAPGEF1 (rs11243444), or NRF1 (rs1882095) increased the risk of type 2 diabetes. PMID: 21146886
- significant positive correlation between layers II and IV of the dorso-lateral prefrontal cortex in the percentage of MR-GEF expressing neurons in individuals with bipolar disorder PMID: 20436929
- C3G overexpression induces neurite-like extensions in MDA-MB-231 and BT549 breast carcinoma cells and not in a variety of other cancer cell lines examined. PMID: 21223981
- C3G as a novel target of c-Abl PMID: 20581864
- ALK activation of Rap1 via the Rap1-specific GEF C3Gmay contribute to cell proliferation and oncogenesis of neuroblastoma. PMID: 20190816
- Cbl-b plays a negative role in Crk-L-C3G-mediated Rap1 and LFA-1 activation in T cells. PMID: 12697763
- C3G and Hck interact physically and functionally in vivo to activate kinase-dependent and caspase-mediated apoptosis, which is independent of catalytic domain of C3G PMID: 14551197
- C3G interferes with at least two separate aspects of oncogenic transformation - cell cycle progression and loss of contact inhibition. PMID: 15077165
- amplification and increased expression of the C3G gene may play some role in human lung carcinogenesis through derangement of the CRK-Rap1 signaling pathway PMID: 15138850
- Src family kinases or pervanadate treatment induces phosphorylation of C3G on Y504. Unlike C3G, which is mostly cytosolic, pY504C3G locates to the Golgi & subcortical actin cytoskeleton, providing evidence for a function for C3G at these compartments. PMID: 15320955
- Inactivation of Crk SH3 domain-binding guanine nucleotide-releasing factor is associated with cervical squamous cell carcinoma PMID: 16681758
- C3G triggers PP2A activation and binding to MEK and ERK at the subcortical actin cytoskeleton, thus favouring ERK dephosphorylation. PMID: 17825818
- Results identify a mechanism by which the WAVE2 complex regulates T cell receptor signaling to Rap1 and integrin activation via Abl- and CrkL-C3G. PMID: 18809728
- Rap1 and its exchange factor C3G in mediating Fc gammaR-dependent phagocytosis. PMID: 18832707
- Genetic polymorphisms in the RAPGEF1 gene and positive association between one polymorphism and type 2 diabetes in the Korean population. PMID: 19297053
- These results strongly suggest a dual regulatory role for C3G in chronic myeloid leukemia cells, modulating both apoptosis and survival via Rap-dependent and independent mechanisms. PMID: 19324082
顯示更多
收起更多
-
亞細(xì)胞定位:Early endosome.
-
組織特異性:Ubiquitously expressed in adult and fetus. Expression is high in adult skeletal muscle and placenta and in fetal brain and heart. Low levels of expression in adult and fetal liver.
-
數(shù)據(jù)庫鏈接:
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IF, FC
Species Reactivity: Human, Mouse, Rat
-
-
-
-
-
-