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RASSF7 Antibody, FITC conjugated

  • 中文名稱：
    RASSF7兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA863596LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RASSF7 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RASSF7
  • 別名：
    C11orf13 antibody; Chromosome 11 open reading frame 13 antibody; HRAS1 antibody; HRAS1 related cluster 1 antibody; HRAS1 related cluster protein 1 antibody; HRAS1-related cluster protein 1 antibody; HRC1 antibody; MGC126069 antibody; MGC126070 antibody; Ras association (RalGDS/AF 6) domain family (N terminal) member 7 antibody; Ras association (RalGDS/AF 6) domain family 7 antibody; Ras association domain containing protein 7 antibody; Ras association domain-containing protein 7 antibody; RASF7_HUMAN antibody; RASSF 7 antibody; RASSF7 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Ras association domain-containing protein 7 protein (300-368AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.
  • 基因功能參考文獻(xiàn)：
    1. RASSF7 promotes cell proliferation through activating MEK1/MEK2-ERK1/ERK2 signaling pathway in hepatocellular carcinoma. PMID: 29729697
    2. Suggest that loss of RASSF7 expression results in apoptosis in nucleus pulposus cells in human intervertebral disc degeneration. PMID: 26884887
    3. truncated RASSF7 could act as an oncogene in a small subset of tumours where it is mutated in this way. PMID: 26569555
    4. The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma. PMID: 22695170
    5. RASSF7 acts in concert with N-Ras to constitute a stress-sensitive temporary mechanism of apoptotic regulation. PMID: 21278800
    6. RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis. PMID: 20629633
    7. rare alleles of HRas1 minisatellite are associated with increased risk of papillary thyroid cancer formation in children and adolescents after Chernobyl accident PMID: 15098441

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  • 亞細(xì)胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with gamma-tubulin.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1166

    OMIM: 143023

    KEGG: hsa:8045

    STRING: 9606.ENSP00000344226

    UniGene: Hs.72925