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RBFOX3 Antibody, FITC conjugated

  • 中文名稱：
    RBFOX3兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA407385LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RBFOX3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RBFOX3
  • 別名：
    FLJ56884 antibody; FLJ58356 antibody; Fox-1 homolog C antibody; fox1 homolog C antibody; Fox3 antibody; FOX3NeuN antibody; hexaribonucleotide binding protein 3 antibody; HRNBP3 antibody; NEUN antibody; neuronal nuclei antibody; Rbfox3 antibody; RFOX3_HUMAN antibody; RNA binding protein fox-1 homolog 3 antibody; RNA binding protein, fox 1 homolog (C. elegans) 3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human RNA binding protein fox-1 homolog 3 protein (1-101AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD).
  • 基因功能參考文獻(xiàn)：
    1. RBFOX3 knockdown synergized with 5-FU to inhibit the growth and invasion of HCC cells through PI3K/AKT and epithelial-mesenchymal transition (EMT) signaling, and promote apoptosis by activating the cytochrome-c/caspase signaling pathway. PMID: 29689552
    2. In human lung tissue, Claudin-1 is higher in RBFOX3-positive cells than in RBFOX3-negative cells. Immunostaining and mRNA quantification revealed that protein levels, but not mRNA levels, of Claudin-1 are increased by RBFOX3. PMID: 28126724
    3. SNPs (rs9900428, rs9907432 and rs7211029) in RBFOX3 associate with sleep latency. PMID: 27142678
    4. this study show that TGF-beta-induced RBFOX3 inhibition plays an important role in epithelial-mesenchymal transition and lung cancer progression PMID: 27432190
    5. NeuN was recently eventually identified as an epitope of Rbfox3. NeuN is highly conserved among species and is stably expressed during specific stages of development. NeuN has been considered to be a reliable marker of mature neurons, however, this role has been challenged by recent studies indicating that NeuN staining is variable and even absent during certain diseases and states. Review. PMID: 25680637
    6. RNA splicing occurs in the nucleus hence, the altered localization of RbFox3 to the cytoplasm may lead to the downregulation of neuronal gene expression. PMID: 24215932
    7. High NeuN levels are associated with supratentorial ependymomas. PMID: 23371454
    8. NeuN immunocytochemical reaction in neurons of human substantia nigra was expressed much weaker than in the nucleus rubrum neurons located in the same sections. PMID: 23898728
    9. NeuN (neuronal nuclei) is a neuron-specific nuclear protein identified by anti-NeuN antibody, and widely used as the postmitotic neuron marker. NeuN is identified as the Fox-3 gene product by mass spectrometry, immunoblotting, RNAi, and immunostaining. PMID: 19713214

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  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 27097

    OMIM: 616999

    KEGG: hsa:146713

    STRING: 9606.ENSP00000393262

    UniGene: Hs.135229