RECQL4 Antibody
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中文名稱:RECQL4兔多克隆抗體
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貨號:CSB-PA019538GA01HU
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規(guī)格:¥3,900
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:RECQL4
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別名:ATP dependent DNA helicase Q4 antibody; ATP-dependent DNA helicase Q4 antibody; DNA helicase antibody; DNA helicase, RecQ like type 4 antibody; RECQ 4 antibody; RECQ L4 antibody; RecQ protein 4 antibody; RecQ protein like 4 antibody; RecQ protein-like 4 antibody; RecQ-like type 4 antibody; RecQ4 antibody; RECQ4_HUMAN antibody; RECQL 4 antibody; RECQL4 antibody; RTS antibody
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宿主:Rabbit
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反應(yīng)種屬:Human
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免疫原:Human RECQL4
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免疫原種屬:Homo sapiens (Human)
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抗體亞型:IgG
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純化方式:Antigen Affinity purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA,WB,IF
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Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點詳情
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功能:DNA-dependent ATPase. May modulate chromosome segregation.
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基因功能參考文獻:
- Data suggest that RECQL4 DNA helicase (RECQL4) modulates the pathway choice of DNA end-joining repair and homologous recombination DNA repair in a cell cycle-dependent manner. PMID: 29229926
- analysis of RECQL4 variants in Chinese patients with Rothmund-Thomson syndrome PMID: 29462647
- RECQL4 is an important participant in homologous recombination (HR)-dependent DNA double-strand break repair. PMID: 27320928
- These results solidify Hrq1 as a true RecQ4 homolog and position it as the premier model to determine how RecQ4 mutations lead to genomic instability and disease. PMID: 28334827
- High RECQL4 expression is associated with Cisplatin Resistance in Gastric Cancer. PMID: 27013200
- Mutations in RECQL4 are responsible for the majority of cases of Rothmund-Thomson syndrome . RECQL4 is important not only in Cancer development but also in the aging process. PMID: 27287744
- High RecQL4 expression is associated with osteosarcoma. PMID: 27813658
- this study demonstrates for the first time that, owing to its mitochondrial functions, the accessory mitochondrial replication helicase RECQL4 prevents the invasive step in the neoplastic transformation process. PMID: 26906415
- These results reveal novel possible roles of RecQ4 in DNA replication and genome stability. PMID: 26888063
- RECQL4 is tumour promoting in established breast cancers PMID: 26690729
- RecQL4-dependent association of Mcm10 and Ctf4 with replication origins appears to be the first important step controlled by S phase promoting kinases and checkpoint pathways for the initiation of DNA replication in human cells. PMID: 25602958
- No RECQL4 mutations were found in the BGS group without poikiloderma, confirming that RECQL4 sequencing was not indicated in this phenotype. PMID: 24635570
- This finding provided the key to unravel the correlation between the RECQL4 genotype and the mild phenotype of the two siblings of Rothmund-Thomson Syndrome. PMID: 24518840
- The N-terminus of human RecQL4 acts as a complex moderator of DNA transactions that are mediated by multiple DNA-binding sites. PMID: 25336622
- The highly cancer-prone RECQ4 ID mutant failed to interact with p32, leading to increases in mtDNA copy number and MT dysfunction. PMID: 24746816
- Dysfunction of RECQL4 increases DNA damage and triggers premature senescence in both human and mouse cells, which may contribute to symptoms in Rothmund-Thompson syndrome patients. PMID: 24832598
- Elevated expression of RECQL4 accompanies progression of the Rothmund-Thomson Syndrome into osteosarcoma in humans and mice. PMID: 24924172
- Molecular analyses show the presence of a novel truncating mutation and of a known missense mutation, p.R1021W, located outside of the helicase domain, which has been found in several patients either in a compound heterozygous state or alone. PMID: 23899764
- In vitro studies showed that defects in RECQL4 impair homologous recombination, sensitizing BC cells to DNA-damaging agents. PMID: 24072219
- RECQL4 and p53 potentiate the activity of polymerase gamma and maintain the integrity of the human mitochondrial genome. PMID: 24067899
- overexpression of RecQL4 due to gene amplification play a critical role in human breast tumor progression PMID: 23894508
- RECQL4 may be uniquely positioned to act as a bridge between cancer and aging, functioning as a guardian not only of the nuclear genome, but also of the mitochondrial genome. PMID: 22940096
- RECQL4 has a preferential activity in vitro on telomeric substrates containing thymine glycol. PMID: 23683351
- Our findings provide further support for a helicase-dependent cellular function of RECQL4 PMID: 23238538
- Nuclear exporting signals -mediated RecQL4 export to the cytoplasm is essential for the maintenance of mitochondrial genome stability. PMID: 22824301
- Despite low-sequence homology, the N-terminus of the human RecQL4 helicase was determined to be a well-defined structure that carries an overall helical fold similar to homeodomain DNA-binding proteins but lacks their archetypical, minor groove-binding N-terminal extension. PMID: 22730300
- Measurements of mitochondrial bioenergetics showed a reduction in the mitochondrial reserve capacity after lentiviral knockdown of RECQL4 in two different primary cell lines. PMID: 22296597
- RECQL4 is essential for the transport of p53 to mitochondria. PMID: 22357944
- BLM and RECQL4 interact physically and functionally in vivo and in vitro. PMID: 22544709
- These observations help explain the underlying molecular etiology of the disease and our findings provide insight into the genotype and phenotype association among RECQL4 syndromes PMID: 22885111
- study concludes that the function of the RecQ helicases has diverged during evolution, with RecQL4 acquiring a function that allows cells to negotiate DNA replication templates that have been damaged by ionizing radiation PMID: 22508716
- Single Nucleotide Polymorphisms in RECQL4 gene is associated with glioblastoma. PMID: 22017238
- function of RECQL4 in telomere maintenance PMID: 22039056
- RecQL4, the N-terminal portion of which shares similarity with Sld2 known to be required for assembly of a replication complex in yeasts, is unique in that it has been shown to be essential for the initiation phase of normal DNA replication. PMID: 21436139
- The N-terminal domain of RECQL4 is sufficient for cell viability. The C-terminal region including the helicase domain of RECQL4 is implicated in DNA repair. PMID: 21256165
- Study shows that RecQL4 is an essential factor for prostate carcinogenesis. PMID: 21045146
- shows that RECQL4 is recruited early to laser-induced double-strand breaks and remains for a shorter duration than WRN and BLM PMID: 20222902
- Together, these data indicate that specific biochemical activities and protein partners of RecQ4 are conserved with those of the other RecQ helicases. PMID: 20451470
- These results indicate that RECQ1 and RECQ4 are integral components of the human replication complex and play distinct roles in DNA replication initiation and replication fork progression in vivo. PMID: 20065033
- The RECQL4 gene structure is unusual because it contains many small introns <100 bp. We describe a proband with Rothmund-Thomson syndrome who has a novel 11-bp intronic deletion; this mutation results in a 66-bp intron too small for proper splicing. PMID: 12016592
- Two novel exonic single nucleotiude polymorphisms and a minisatellite repeat are characterized. PMID: 12601557
- RECQL4 mutations were not found in poikiloderma with neutropenia in Navajo and non-Navajo patients PMID: 12673665
- RECQL4 gene is not a frequent target for somatic mutations in sporadic osteosarcoma. PMID: 15221963
- RECQL4 from HeLa cells interacts with ubiquitin ligases UBR1 and UBR2. PMID: 15317757
- The human diseases connected with RECQL4 mutations appear distinct in their clinical phenotypes from Bloom or Werner's symdrome. PMID: 15960976
- Baller-Gerold syndrome (BGS) in a subgroup of patients is due to RECQL4 mutations and could be integrated into a clinical spectrum that encompasses Rothmund-Thomson syndrome (RTS) and RAPADILINO syndrome. PMID: 15964893
- Findings suggest a role for RECQL4 in the repair of DNA double-strand breaks by homologous recombination and shed new light onto RECQL4's function in human cells. PMID: 16141230
- RECQ4 lacks a detectable DNA helicase activity and is mutated in Rothmund-Thomson syndrome PMID: 16214424
- It is especially difficult to draw precise genotype-phenotype correlations in RECQL4 related syndromes. This is likely due to the complex and multiple cellular networks RECQL4 is associated with. PMID: 16617241
- These results suggest that enhanced oxidant sensitivity in RECQL4 deficient fibroblasts derived from RTS patients could be attributed to abnormal DNA metabolism and proliferation failure. PMID: 16678792
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相關(guān)疾?。?/div>Rothmund-Thomson syndrome (RTS); RAPADILINO syndrome (RAPADILINOS); Baller-Gerold syndrome (BGS)亞細胞定位:Cytoplasm. Nucleus.蛋白家族:Helicase family, RecQ subfamily組織特異性:Ubiquitously expressed, with highest levels in thymus and testis.數(shù)據(jù)庫鏈接:
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