RGS4 Antibody
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中文名稱:RGS4兔多克隆抗體
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貨號:CSB-PA019656LA01HU
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規(guī)格:¥440
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促銷:
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圖片:
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱:Rabbit anti-Homo sapiens (Human) RGS4 Polyclonal antibody
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Uniprot No.:
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基因名:RGS4
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別名:MGC2124 antibody; MGC60244 antibody; Regulator of G protein signalling 4 antibody; Regulator of G-protein signaling 4 antibody; RGP 4 antibody; RGP4 antibody; RGS 4 antibody; RGS4 antibody; RGS4_HUMAN antibody; Schizophrenia disorder 9 antibody; SCZD 9 antibody; SCZD9 antibody
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宿主:Rabbit
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反應(yīng)種屬:Human
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免疫原:Recombinant Human Regulator of G-protein signaling 4 protein (1-205AA)
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
本頁面中的產(chǎn)品,RGS4 Antibody (CSB-PA019656LA01HU),的標(biāo)記方式是Non-conjugated。對于RGS4 Antibody,我們還提供其他標(biāo)記。見下表:
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:>95%, Protein G purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA, IHC, IF
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推薦稀釋比:
Application Recommended Dilution IHC 1:20-1:200 IF 1:50-1:200 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點詳情
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功能:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
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基因功能參考文獻(xiàn):
- Study investigated whether RGS4 could participate in signalling pathways to regulate neurotropic events. These observations suggest that RGS4 is implicated in opioid dependent neuronal differentiation and neurite outgrowth via a "non-canonical" signaling pathway regulating STAT5B-directed responses. PMID: 28219718
- Data support the notion that the Galpha, but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 activation and unveil new roles for RGS and RGS4 in fine-tuning TRPC4 activities. PMID: 26987813
- The results of this study demonstrated the association between the variation in the regulator of G-protein signaling 4 (RGS4) gene, a putative candidate gene for psychosis previously associated with schizophrenia endophenotypes, and psychotic-like experiences (PLEs). PMID: 26910404
- All of these results confirmed the critical role of RGS4 in NSCLC progression. PMID: 26640232
- After alphao dissociates from MOR, RGS4 remains bound to the C-terminal region of MOR PMID: 26119705
- RGS4 deletion results in a predisposition to atrial fibrillation from enhanced activity in the G-protein pathway, resulting in abnormal calcium release and corresponding electrical events. PMID: 26088132
- RGS2 and RGS4 are new interacting partners that play key roles in G protein coupling to negatively regulate kappa-OmicronR signaling. PMID: 25289860
- RGS4 and COMT risk variants are associated with brain structural alterations in patient with schizophrenia. PMID: 23911251
- genetic association study in Chinese Han population: Data suggest an SNP in RGS4 (rs10759) is associated with increased predisposition to schizophrenia via down-regulation of miroRNA (MIRN124) binding to 3-prime-untranslated region of RGS4 mRNA. PMID: 23332465
- The results suggest unaltered membrane RGS4 and cytosolic RGS10 proteins levels in schizophrenia and major depression. PMID: 23093381
- dramatic up-regulation of RGS4 expression in the nucleus accumbens of subjects treated with monoamine-directed antidepressants PMID: 23630294
- Lack of association between the regulator of G-protein signaling 4 (RGS4) rs951436 polymorphism and schizophrenia. PMID: 22157635
- Cys-2 and Cys-12 play markedly different roles in the regulation of RGS4 membrane localization, intracellular trafficking, and G(q) inhibitory function via mechanisms that are unrelated to RGS4 protein stabilization. PMID: 22753418
- RGS4 gene variations specifically disrupt prefrontal control of saccadic eye movements. PMID: 21910931
- These studies indicate that increased RGS4 expression promotes a phenotypic switch of airway smooth muscle, evoking irreversible airway obstruction in subjects with severe asthma. PMID: 22253691
- The researchers found evidence that there were significant differences between the D1S1656 locus in the Maghreb population and other populations. PMID: 21674833
- RGS4 and RGS10 proteins are detected in postmortem prefrontal cortex. PMID: 20816714
- Opioid-induced down-regulation of RGS4: role of ubiquitination and implications for receptor cross-talk. PMID: 21209077
- RGS4 polymorphisms are associated with variations in cognitive functions and contribute a small but statistically significant proportion of variance in a family-based sample. PMID: 19282471
- Localization of Sst2 to the projection prevents excess G-protein activation during the pheromone response. PMID: 20712983
- RGS4 is a potential susceptible gene for bipolar disorder. PMID: 20414142
- A novel mechanism involving coordinated regulation of nuclear levels and acetylation of NF-YA and Bcl6 activates RGS4 transcription. PMID: 20630860
- A homogeneous sample of 280 schizophrenia patients and 230 healthy controls of Hungarian, Caucasian descent were genotyped for polymorphisms in schizophrenia candidate genes NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A. PMID: 19937977
- cytosolic and membrane levels of RGS4 may contribute to the regional differences in the coupling of muscarinic M1 receptors in Alzheimer's disease PMID: 12422374
- A significant decrease in the transcript encoding regulator of G-protein signaling 4 (RGS4) in the prefrontal cortex of patients with schizophrenia. PMID: 12436019
- results suggest that palmitoylation of a Cys residue in the regulator of G protein signaling(RGS) box is critical for RGS16 and RGS4 GAPase activating protein activity and their ability to regulate G protein signaling in mammalian cells PMID: 12642592
- The data of this research give modest support for the hypothesis that the regulator of G-protein signaling 4 is a susceptibility gene for schizophrenia. PMID: 14732600
- RGS4 mRNA distribution in human postmortem tissue from normal persons was very dense in most cortical layers examined, with lower density in the basal ganglia and thalamus. PMID: 15182322
- Results could be interpreted as supporting evidence for the association between RGS4 and schizophrenia. PMID: 15274033
- RGS4 and beta-tubulin modulate Galpha-GDP and Galpha-GTP states thus modulating MT1 melatonin receptor function. PMID: 15369705
- RGS4 polymorphisms are associated with alterations in dorsolateral prefrontal cortex (area 9) volumes among schizophrenic patients. PMID: 15381923
- Although gross indices of signaling were unaffected by RGS4, it slowed the rate of increase in Ins(1,4,5)P3 levels. PMID: 15383626
- In schizophrenia, significant case-control differences were not observed, though the TDT suggested transmission distortion. For bipolar disorder, an omnibus test suggested differences in the overall distribution of haplotypes bearing all four SNPs. PMID: 15660667
- No association is identified between RGS4 single nucleotide polymorphism (SNP) markers, genotypes, or haplotypes and schizophrenia PMID: 16082709
- Data do not directly replicate previous associations of RGS4, but association with SNP 7 in the Scottish population provides some support for a role in schizophrenia susceptibility. PMID: 16176390
- These results provide the first demonstration of a Ca(2+)-dependent interaction between RGS4 and CaM in vivo and show that association in lipid rafts of the plasma membrane might be involved in this physiological regulation of RGS proteins. PMID: 16246308
- Finding weakens the evidence that mutations or variation in the RGS4 gene have an effect on schizophrenia susceptibility. PMID: 16508931
- Results fail to support the RGS4 as a candidate gene for schizophrenia when evaluated with three SNP markers from promoter region and intron 1. PMID: 16526029
- RGS4 is an example of a molecule that may underlie increased vulnerability through either genetic or non-genetic mechanisms, which we suggest may be typical of other genes in a complex, polygenic disorder such as schizophrenia. PMID: 16860780
- Genetic polymorphisms within RGS4 are unlikely to confer an increased susceptibility to the etiology of schizophrenia. PMID: 16904822
- RGS4 mRNA was inversely correlated with COMT enzyme activity in the dorsolateral prefrontal cortex PMID: 16905560
- SNPs in RGS4, G72, GRM3, and DISC1 showed evidence for significant statistical epistasis with COMT. PMID: 17006672
- RGS4 single nucleotide polymorphism impacts frontal lobe blood oxygenation level-dependent response and network coupling during working memory and results in reductions in gray, white matter structural volume in individuals carrying the A allele. PMID: 17301167
- In RGS4, the G-allele of the previously reported SNP RGS4-1 (single and as part of haplotypes with SNP RGS4-18) was associated with non-deficit schizophrenia but not with deficit schizophrenia. PMID: 17410640
- study identified all common RGS4 polymorphisms & evaluated patterns of linkage disequilibrium in relation to schizophrenia; 2 haplotypes reported to confer liability to SZ had significant promoter activity suggesting functional role for both haplotypes PMID: 17515439
- RGS4 genotypes predicted both the severity of baseline symptoms and relative responsiveness to antipsychotic treatment in patient with schizophrenia. PMID: 17588543
- Full length cloning and expression analysis of splice variants of RGS4 were performed. PMID: 17707117
- the association of regulator of G-protein signalling 4 protein polymorphisms with the phenotypic subgroups of schizophrenia. PMID: 17722013
- The isolation and characterization of a novel human RGS4 mutant which displays enhanced or gain-of-function (GOF) activity, is described. PMID: 18031991
- RGS4 variances influence clinical manifestations of schizophrenia PMID: 18204343
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相關(guān)疾?。?/div>Schizophrenia (SCZD)組織特異性:Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum.數(shù)據(jù)庫鏈接:
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