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RGS9BP Antibody, Biotin conjugated

  • 中文名稱：
    RGS9BP兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA765076LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RGS9BP Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RGS9BP
  • 別名：
    RGS9BP antibody; R9AP antibody; Regulator of G-protein signaling 9-binding protein antibody; RGS9-anchoring protein antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Regulator of G-protein signaling 9-binding protein (1-210AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation.
  • 基因功能參考文獻：
    1. Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator) PMID: 19948975
    2. This is the first report describing a nonsense mutation in RGS9. PMID: 19818506
    3. five unrelated patients with recessive mutations in the genes encoding either RGS9 or R9AP who report difficulty adapting to sudden changes in luminance levels mediated by cones PMID: 14702087
    4. homozygous mutations in R9AP gene that encodes the photoreceptor GTPase accelerating protein and its anchor protein, respectively, have been identifird in patients with bradyopsia. PMID: 17698770
    5. As the light level is increased and the PDE6* concentration in the normal rises relative to that in the observer lacking RGS9-1, the temporal advantage of the latter is soon lost, leaving only the deficit due to delayed deactivation. PMID: 18318613

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  • 相關(guān)疾病：
    Prolonged electroretinal response suppression (PERRS)
  • 亞細胞定位：
    Membrane; Single-pass type IV membrane protein.
  • 蛋白家族：
    RGS7BP/RGS9BP family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30304

    OMIM: 607814

    KEGG: hsa:388531

    STRING: 9606.ENSP00000334134

    UniGene: Hs.528491