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  4. RHOC Antibody, Biotin conjugated

RHOC Antibody, Biotin conjugated

  • 中文名稱：
    RHOC兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA019687LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RHOC Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RHOC
  • 別名：
    Aplysia RAS-related homolog 9 antibody; ARH 9 antibody; ARH9 antibody; ARHC antibody; H9 antibody; MGC1448 antibody; MGC61427 antibody; Oncogene RHO H9 antibody; Ras homolog gene family member C antibody; RAS related homolog 9 antibody; RHO C antibody; Rho cDNA clone 9 antibody; Rho related GTP binding protein RhoC antibody; Rho-related GTP-binding protein RhoC antibody; rhoC antibody; RhoC GTPase antibody; RHOC_HUMAN antibody; RHOH 9 antibody; RHOH9 antibody; Small GTP binding protein RhoC antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Rho-related GTP-binding protein RhoC protein (1-190AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.
  • 基因功能參考文獻：
    1. LncRNA TDRG1 overexpression induced tumor development and RhoC expression. PMID: 28984384
    2. Studied the involvement in epithelial ovarian cancer (EOC) of lncRNA ABHD11-AS1 in and the regulation of EOC by RhoC. PMID: 28818073
    3. YMO1 suppresses tumor invasion and metastasis by inhibiting RhoC activity. PMID: 27487132
    4. this studies show the ability of miR-10b to activate the expression of c-Jun through RhoC and NF1, which represents a novel pathway for promoting migration and invasion of human cancer cells PMID: 27494896
    5. swapping residue 188 identity effectively flips the membrane binding profile of wild-type RhoA and RhoC through positive arginine contribution rather than negative phosphoserine regulation PMID: 27355867
    6. HOTAIR is regulated by the RhoC-MRTF-A-SRF signaling pathway in breast cancer cells. PMID: 28069441
    7. E2F transcription factor 1 (E2F1) downregulated micrRNA miR-519d directly and miR-519d downregulated Ras homolog gene family member C (RhoC) directly. PMID: 28146423
    8. During the process of epithelial-mesenchymal transition in A549 cells induced by TGF-beta1, upregulated RhoC protein and RhoC activity were detected, which was associated with the enhanced invasive capability of the cells in vitro. PMID: 27748883
    9. RhoC downregulation may inhibit the proliferation, drug resistance, invasion and migration of ovarian cancer stem cells. PMID: 27748937
    10. Downregulation of RHOC inhibited cholangiocellular carcinoma cells invasion and migration partially via inhibition of matrix metalloproteinase 2, 3 and 9 expression. RHOC also modulated the expression of several epithelial-mesenchymal transition (EMT)-associated proteins PMID: 27108649
    11. RT-PCR and Western blot assays demonstrated that miR-372 transfection reduced the expression of RhoC. PMID: 26673619
    12. study has identified several new proteins like RHOC, DLG5, UGDH, TMOD3 in addition to known chemoresistance associated proteins in non-small cell lung carcinoma. PMID: 26898345
    13. the oncogene RhoC, a driver of metastatic potential, modulates glutamine and N-acetylaspartate metabolism in Inflammatory Breast Cancer cells in vitro, revealing a novel role for RhoC as a regulator of tumor cell metabolism that extends beyond its well known role in cytoskeletal rearrangement. PMID: 27129239
    14. The knockdown of RhoC protein decreased the proliferation rate of the parental and the IE1-expressing glioblastoma cells. PMID: 26741994
    15. found that miR-10b induced HCC cell invasion and migration by modulating the HOXD10 target gene RhoC, uPAR, MMP-2 and MMP-9 expression PMID: 25236186
    16. Smart particles encapsulating the scrambled siRNA sequence did not affect RhoC protein expression. PMID: 26020100
    17. Depletion of the kinases ROCK1 and ROCK2, two known RhoC downstream effectors, similarly decreases cancer interaction with ECs PMID: 25677806
    18. Results identify RhoC as a prominent binding partner of RhoGDI2 and show that RhoGDI2 modulates RhoC activity in cells promoting lung colonization of bladder cancer cells. PMID: 25516960
    19. Inhibition of ovarian epithelial carcinoma tumorigenesis and progression by miR106b proceeds through the RhoC pathway. PMID: 25933027
    20. MiR-93-5P may inhibit EOC tumorigenesis and progression by targeting RhoC. PMID: 25649143
    21. miR-509 has a critical role in brain metastasis of breast cancer by modulating the RhoC-TNF-alpha network. PMID: 25659578
    22. RhoC protein may upregulate VEGF expression, thereby promoting tumor angiogenesis in esophageal squamous cell carcinoma. PMID: 25624724
    23. This is the first report in HNSCC demonstrating the role RhoC plays in mediating EGF-stimulated migration and invasion by down-regulating the PI3K-Akt pathway and E-cadherin expression. PMID: 25622907
    24. may contribute to an epithelial-mesenchymal transition and drug resistance in human breast cancer during chemotherapy PMID: 25123151
    25. RhoC expression might be involved in epithelial-to-mesenchymal transition of ovarian epithelial carcinoma cells. PMID: 24986540
    26. Down-regulation of RhoC expression resulted in decreased migration of neural stem cells. PMID: 24414340
    27. RhoC has a role in regulating cancer stem cells in head and neck squamous cell carcinoma through the over expression of IL-6 and phosphorylation of STAT3 PMID: 24533098
    28. The S1P2R specifically activates RhoC via G12/13 proteins and LARG. PMID: 23993968
    29. RhoC/ROCK1 signaling pathways are likely involved in the progression of cervical squamous cell carcinoma PMID: 24457551
    30. RhoC facilitates tumor cell invasion and promotes subsequent metastasis, in part, by enhancing integrin alpha5beta1 trafficking PMID: 24312560
    31. The up-regulated RhoC expression may affect ovarian carcinogenesis and should be considered a good biomarker for the differentiation and progression of ovarian carcinoma PMID: 23764197
    32. Increased RHOC expression was detected in endometriotic lesions compared to the eutopic endometrium of women with endometriosis and control women. PMID: 23302395
    33. HBx and HBs of hepatitis B virus could increase expression of Ets-1, which consequently contributed to the upregulation of RhoC. PMID: 23474984
    34. This study demonstrated the role of RhoC overexpression in malignant transformation of normal human hepatocytes, suggesting that RhoC may function as an oncogene in hepatocytes. PMID: 23382905
    35. data suggest that RhoC is a key regulator of cell growth and apoptosis in human hepatocellular carcinoma cells PMID: 21674277
    36. RhoC stimulates the proliferation of gastric cancer cells through recruiting IQGAP1 as an effector. PMID: 23145020
    37. MRK is a novel RhoC effector that controls LPA-stimulated cell invasion at least in part by regulating myosin dynamics, ERK and p38 PMID: 23319595
    38. Increased prostate RhoC expression predicted a good outcome after radical prostatectomy for high-grade prostate cancer. PMID: 22935975
    39. RhoC impacts the metastatic potential and abundance of breast cancer stem cells. PMID: 22911725
    40. Substitution of RhoC Ile 43 with a Val increased guanine nucleotide exchange factors-catalyzed exchange in vitro. PMID: 22673745
    41. Knockdown of Hop caused a decrease in the level of RhoC GTPase, and significantly inhibited pseudopodia formation in Hs578T cells. Our data suggest that Hop regulates directional cell migration by multiple unknown mechanisms. PMID: 23036489
    42. Data demonstrate that PKN3 physically interacts with Rho-family GTPases, and preferentially with RhoC, a known mediator of tumor invasion and metastasis in epithelial cancers. PMID: 22217540
    43. Suggest that miR-10b can stimulate the upregulation of RhoC and AKT phosphorylation through targeting HOXD10, thus promoting cell invasion in gastric tumors. PMID: 22293682
    44. miR-493 is a new tumor suppressor miRNA in bladder cancer and inhibits cell motility through downregulation of RhoC and FZD4. PMID: 22057916
    45. In a signaling cascade, the loss of E-cadherin activates the transcriptional regulator ETS-1 and consequently leads to the induction of RhoC expression that stabilizes c-Jun in melanoma. PMID: 21732343
    46. Expression levels of RhoC and ROCK-1 in prostate carcinoma are higher than those in corresponding paracancerous tissues, showing a significant positive correlation with distant metastasis. PMID: 21575520
    47. p38gamma mitogen-activated protein kinase regulates breast cancer cell motility and metastasis, in part, by controlling expression of the metastasis-associated small GTPase RhoC. PMID: 21862636
    48. RHOC expression was induced by direct p53 binding to a regulatory element within the RHOC gene. PMID: 21079653
    49. The knockdown of RhoC expression had no effect on the migration-stimulatory activity of IQGAP1. PMID: 21537845
    50. RhoC promotes polarized tumor cell migration through FMNL3 by restricting lamellipodial broadening. PMID: 21576392

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  • 亞細(xì)胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.
  • 蛋白家族：
    Small GTPase superfamily, Rho family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 669

    OMIM: 165380

    KEGG: hsa:389

    STRING: 9606.ENSP00000285735

    UniGene: Hs.502659