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  4. RNASEH2B Antibody
  • 中文名稱：
    RNASEH2B兔多克隆抗體
  • 貨號(hào)：
    CSB-PA019806GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    RNASEH2B
  • 別名：
    RNASEH2B antibody; DLEU8 antibody; Ribonuclease H2 subunit B antibody; RNase H2 subunit B antibody; Aicardi-Goutieres syndrome 2 protein antibody; AGS2 antibody; Deleted in lymphocytic leukemia 8 antibody; Ribonuclease HI subunit B antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human RNASEH2B
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
  • 基因功能參考文獻(xiàn)：
    1. Results implicate rare variants in the Aicardi-Goutieres syndrome genes ADAR and RNASEH2B and a type I interferon signature in glioma and prostate carcinoma risk and tumorigenesis, consistent with a genetic basis underlying inflammation-driven malignant transformation in glioma and prostate carcinoma development. PMID: 29030706
    2. This study reviewed that Neurologic Phenotypes Associated with Mutations in RNASEH2B in patients with Aicardi-Goutieres Syndrome. PMID: 27643693
    3. Aicardi-Goutieres syndrome 2 is caused by mutations in the ribonuclease H2 subunit B gene RNASEH2B. PMID: 25906927
    4. RNase H2 complex is assembled in the cytosol and imported into the nucleus in an RNase H2B-dependent manner. PMID: 24986920
    5. A genome-wide search for homozygosity in Aicardi-Goutieres syndrome patients in the Faroe Islands revealed one single 15.6 Mb region of homozygosity on chromosome 13, which included RNASEH2B, where a splice site mutation c.322-3C>G was identified. PMID: 22882256
    6. This study demonistrated that ribonuclease H2 mutation releated to Aicardi-Goutieres syndrome. PMID: 21862834
    7. Congenital infection is seen with preserved neurological function, most frequently due to RNASEH2B mutations. PMID: 18422679
    8. Examination of the effect of several Aicardi-Goutieres Syndrome-related mutations in the B subunit of RNase H2. PMID: 19015152
    9. patients with genetic deficiency develop the spontaneous inflammatory myocarditis PMID: 19120481

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  • 相關(guān)疾病：
    Aicardi-Goutieres syndrome 2 (AGS2)
  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    RNase H2 subunit B family
  • 組織特異性：
    Widely expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 25671

    OMIM: 610181

    KEGG: hsa:79621

    STRING: 9606.ENSP00000337623

    UniGene: Hs.306291