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RNF34 Antibody

  • 中文名稱：
    RNF34兔多克隆抗體
  • 貨號(hào)：
    CSB-PA019886GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    RNF34
  • 別名：
    CARP 1 antibody; CARP-1 antibody; CARP1 antibody; Caspase regulator CARP1 antibody; Caspases-8 and -10-associated RING finger protein 1 antibody; E3 ubiquitin-protein ligase RNF34 antibody; FYVE-RING finger protein Momo antibody; hRFI antibody; Human RING finger homologous to inhibitor of apoptosis protein antibody; RFI antibody; RIF antibody; RIFF antibody; RING finger protein 34 antibody; RING finger protein RIFF antibody; RNF34 antibody; RNF34_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human RNF34
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells. Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation.
  • 基因功能參考文獻(xiàn)：
    1. Data indicate that E3 ligase RNF34 is associated with nucleotide-binding oligomerization domain-containing protein 1 (NOD1). PMID: 25012219
    2. Data indicate AE induces caspase-8-mediated activation of mitochondrial death pathways by decreasing the stability of CARP mRNAs in a p53-independent manner. PMID: 21308745
    3. The previously unknown small molecule inhibitor-dependent interaction of Cbeta1 with the cell cycle and apoptosis regulatory protein-1 was verified. PMID: 20564261
    4. a novel gene, hRFI, preferentially expressed in esophageal cancer (hRFI) PMID: 12118383
    5. hRFI may act as an oncogenic molecule affecting the apoptotic pathway PMID: 15595643
    6. CARPs together with MDM2 enhance p53 degradation, thereby inhibiting p53-mediated cell death. PMID: 18382127

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  • 亞細(xì)胞定位：
    Cell membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Nucleus. Nucleus speckle. Cytoplasm, cytosol.
  • 組織特異性：
    Ubiquitous. Detected in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon and leukocytes.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 17297

    OMIM: 608299

    KEGG: hsa:80196

    STRING: 9606.ENSP00000376258

    UniGene: Hs.292804