ROMO1 Antibody, HRP conjugated
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中文名稱:ROMO1兔多克隆抗體, HRP偶聯(lián)
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貨號:CSB-PA020063LB01HU
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規(guī)格:¥880
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱:Rabbit anti-Homo sapiens (Human) ROMO1 Polyclonal antibody
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Uniprot No.:
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基因名:ROMO1
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別名:ROMO1; C20orf52; Reactive oxygen species modulator 1; ROS modulator 1; Epididymis tissue protein Li 175; Glyrichin; Mitochondrial targeting GxxxG motif protein; MTGM; Protein MGR2 homolog
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宿主:Rabbit
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反應(yīng)種屬:Human
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免疫原:Recombinant Human Reactive oxygen species modulator 1 protein (45-79AA)
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免疫原種屬:Homo sapiens (Human)
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標記方式:HRP
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:>95%, Protein G purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA
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Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點詳情
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功能:Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.; Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
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基因功能參考文獻:
- Romo1 overexpression was associated with poor response to treatment and shorter survival in advanced NSCLC patients treated with platinum-based chemotherapy. Romo1 could be a potential adverse predictive marker in this setting. PMID: 27188201
- Increased Romo1 expression was found to be associated with high lymph node ratio. Cancer invasiveness appeared to be a key reason for the poor survival related to highly expressed Romo1 PMID: 28472059
- the diagnostic sensitivity and specificity of serum reactive oxygen species modulator 1 were only 41.38% and 86.21%, respectively, with the cutoff value of 27.22 ng/mL. The sensitivity and specificity of pleural fluid carcinoembryonic antigen were 69.23% and 88.00%, respectively, at the cutoff value of 3.05 ng/mL, while serum carcinoembryonic antigen were 80.77% and 72.00% at the cutoff value of 2.60 ng/mL. PMID: 28459208
- elevated in pleural effusion when lung cancer present PMID: 28121949
- The rs6060566 polymorphism of the Romo-1 gene was found to be an independent risk factor for DR in Caucasians with T2DM. PMID: 25824963
- Genetic polymorphisms of Romo1 gene were associated with significant risk of gastric cancer. PMID: 25374412
- These results demonstrate that tumor cell invasion in response to oxidative stress is associated with Romo1 expression and the NF-kappaB signaling pathway. PMID: 25673177
- Results demonstrate that expression of Romo1 is frequently upregulated in human glioblastomas and its elevation promotes malignant tumor progression by promoting cell cycle progression and by enhancing tumorigenicity PMID: 25193023
- Increased Romo1 expression in surgically resected NSCLC was found to be significantly associated with early recurrence and poor survival. Romo1 overexpression could be a potential adverse prognostic marker in this setting. PMID: 25468147
- Serum Romo1 discriminated NSCLC patients from the population without cancer with considerable sensitivity and specificity. Serum Romo1 could be a potential diagnostic biomarker for NSCLC. PMID: 24951318
- High ROMO1 expression is associated with Fanconi anemia. PMID: 25687884
- Romo1 may be a principal regulatory factor in the maintenance of constitutive NF-kappaB activation in tumor cells PMID: 25044121
- that ROS modulator protein 1 (ROMO1) links ROS and mitochondrial morphology and ultrastructure by modulating cristae remodeling and mitochondrial fusion PMID: 24473193
- data identify ROMO1 as a critical molecular switch that couples metabolic stress and mitochondrial morphology, linking mitochondrial fusion to cell survival. PMID: 24473195
- This study is the first to demonstrate that strict modulation of DKK1 expression in different cell types partially maintains cell survival via tight regulation of the ROS-producing ROMO1 and radiation resistance. PMID: 24269823
- Romo1 mediates mitochondrial reactive oxygen species production and apoptosis induced by oxidative stress in lung epithelial cells. PMID: 23867822
- A 19 amino acid peptide (pCM19) at positions 42-60 of hGlyrichin is crucial for its antibacterial activity. PMID: 22083756
- Romo1 expression induced by Myc during G1 phase stimulates Skp2-mediated Myc degradation in a negative-feedback mechanism PMID: 21558421
- increased Bcl-XL expression, which is observed in many cancer cells, confers resistance to oxidative stress in the cancer cells by suppressing Romo1-mediated oxidative stress. PMID: 21399876
- Romo1 and Bcl-X(L)) are directly associated with TNF-alpha-induced ROS production. Romo1 is a molecular bridge between TNF-alpha signaling and the mitochondria for ROS production that triggers TNF-alpha-mediated apoptosis. PMID: 20203691
- Romo1-derived reactive oxygen species play an important role in apoptotic cell death triggered by withdrawal of cell survival factors. PMID: 19904609
- Mitochondrial ROS generated by Romo1 expression are required for normal cell proliferation. Romo1 plays an important role in redox signalling during normal cell proliferation. PMID: 19513905
- Results suggest that MTGM is an integral mitochondrial inner-membrane protein that coordinately regulates mitochondrial morphology and cell proliferation. PMID: 19535734
- cellular adaptive response to Romo1-induced ROS is a mechanism of drug resistance to 5-FU PMID: 17537404
- The results of this study suggest that Romo1-induced ROS may play an important role in redox signaling in cancer cells. PMID: 18313394
- age-related ROS levels increase, and this contributes to replicative senescence, which is directly associated with Romo1 expression. PMID: 18836179
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亞細胞定位:Mitochondrion inner membrane; Single-pass membrane protein.
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蛋白家族:MGR2 family
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組織特異性:Up-regulated in a number of cancer cell lines when compared to a normal lung fibroblast cell line. Highly expressed in brain tumors.
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