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  4. RPS27A Antibody, HRP conjugated

RPS27A Antibody, HRP conjugated

  • 中文名稱：
    RPS27A兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA01639B0Rb
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RPS27A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RPS27A
  • 別名：
    RPS27A antibody; UBA80 antibody; UBCEP1 antibody; Ubiquitin-40S ribosomal protein S27a antibody; Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; 40S ribosomal protein S27a antibody; Small ribosomal subunit protein eS31)] antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Ubiquitin-40S ribosomal protein S27a protein (16-56AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.; Component of the 40S subunit of the ribosome.
  • 基因功能參考文獻：
    1. this study shows that interactions of antisera to different Chlamydia and Chlamydophila species with the ribosomal protein RPS27a correlate with impaired protein synthesis in a human choroid plexus papilloma cell line PMID: 28913776
    2. the full-length cDNA sequence of MMSA-8 was cloned in MM and it was hypothesized that MMSA-8 is MM-associated RPS27A transcript variant 1 PMID: 28498418
    3. RPS27a enhances viral LMP1-mediated proliferation and invasion, suggesting that RPS27a interacts with LMP1 and stabilizes it by suppressing proteasome-mediated ubiquitination. PMID: 28735865
    4. Imatinib-resistant K562/G01 cells expressed significantly higher levels of STAT3 and RPS27a compared with those of K562 cells. PMID: 26942564
    5. RPS27A expression was found to have a weak inverse correlation with overexpression of multifunctional protein YB-1 in HCC tissues. PMID: 24833360
    6. RPS27a appears to be a novel stress sensor in the cell which amplifies p53 response to arrest cell cycle. PMID: 25592822
    7. Knockdown of RPS27a inhibits the proliferation, induces cell cycle arrest and potentiates the effect of imatinib on apoptosis of K562 cells. PMID: 24680683
    8. Gene expression profiles showed that RPS27A was down-regulated in epidermolysis bullosa subtypes. PMID: 22716248
    9. S27a plays a non-redundant role in mediating p53 activation in response to ribosomal stress via interplaying with MDM2. PMID: 21561866
    10. ubiquitin carboxyl extension protein 1 is overexpressed in prostate cancer PMID: 15647830

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  • 亞細胞定位：
    [Ubiquitin]: Cytoplasm. Nucleus.
  • 蛋白家族：
    Ubiquitin family; Eukaryotic ribosomal protein eS31 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10417

    OMIM: 191343

    KEGG: hsa:6233

    STRING: 9606.ENSP00000272317

    UniGene: Hs.311640