SAA1 Antibody, Biotin conjugated
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中文名稱:SAA1兔多克隆抗體, Biotin偶聯(lián)
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貨號:CSB-PA14047D0Rb
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規(guī)格:¥880
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱:Rabbit anti-Homo sapiens (Human) SAA1 Polyclonal antibody
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Uniprot No.:
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基因名:SAA1
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別名:SAA1 antibody; Serum amyloid A-1 protein antibody; SAA) [Cleaved into: Amyloid protein A antibody; Amyloid fibril protein AA); Serum amyloid protein A(2-104); Serum amyloid protein A(3-104); Serum amyloid protein A(2-103); Serum amyloid protein A(2-102); Serum amyloid protein A(4-101)] antibody
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宿主:Rabbit
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反應(yīng)種屬:Human
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免疫原:Recombinant Human Serum amyloid A-1 protein (20-122AA)
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Biotin
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:>95%, Protein G purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA
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Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Major acute phase protein.
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基因功能參考文獻(xiàn):
- SAA1 can be produced in human fetal membranes, which can be greatly induced in the presence of proinflammatory cytokines and glucocorticoids thereby producing effects associated with parturition PMID: 28386088
- High SAA1 expression in the stromal component is associated with pancreatic tumors. PMID: 29351990
- Data suggest that anti-inflammatory capacity of HDL (high-density lipoprotein) from patients with type 2 diabetes and diabetic nephropathy is impaired; this effect might be attributable to SAA enrichment in HDL in these patients; up-regulation of SAA in HDL appears to be associated with increased risk of diabetic angiopathy or vasculitis in such patients. PMID: 28760652
- The frequencies of the CC genotype and the C allele of SAA rs12218 were higher in participants with ischemic stroke than in the control group. The frequencies of the AG genotype and the G allele of rs2468844 were higher in participants with ischemic stroke than in the control group. Multiple logistic regression analysis revealed the significance of the rs12218 in males and in large-artery atherosclerosis group. PMID: 28870546
- we show that astrocytoma patients have increased levels of serum SAA and SAA1 is expressed and secreted in glioblastoma, and its co-expression with tumor-related genes supports its involvement in glioblastoma angiogenesis and progression. PMID: 28283801
- These results suggested that the C-terminal truncation of human SAA accelerates amyloid fibril formation. PMID: 29288051
- SAA1 can be a potential mediator for UV-induced MMP-1 expression in human skin. PMID: 26900010
- Data suggest that serum amyloid A (SAA) immunoreactivity in tumor-associated macrophage (TAM) is associated with worse recurrence-free survival, and is perhaps a therapeutic target for breast cancer. PMID: 27058895
- Findings indicate that in Lyme disease patients, circulating CRP and SAA (Serum Amyloid A) levels are highest when the concentration of spirochetes is greatest in skin and/or blood and that levels decline after the dissemination of the organism to extracutaneous sites in subsequent stages of infection. PMID: 27585799
- The Serum amyloid A (SAA)/formyl peptide receptor-like 1 (FPRL1) contributed to pathogenesis of psoriasis by promoting keratinocyte proliferation and inflammation, thus providing a potential therapeutic target for disease therapy. PMID: 27910163
- High SAA expression is associated with lung cancer. PMID: 27809798
- SAA, PROZ, and C4BPB may serve as new potential biomarkers for TB PMID: 28278182
- Novel truncated form of serum amyloid A is elevated in the plasma of Kawasaki disease (KD) when compared with Febrile control subjects. Future studies will evaluate its relevance as a diagnostic biomarker and its potential role in the pathophysiology of KD. PMID: 27271757
- SR-A1 suppresses lung cancer metastasis by downregulating SAA1 production in tumor-associated macrophages (TAM). PMID: 28202524
- The SAA1.1 allele was found in four familial Mediterranean fever patients, including two with AA amyloidosis. PMID: 27150194
- genetic variants at the CRP and SAA1 loci independently affect both CRP and SAA levels, and their respective circulating levels act as suppressors. PMID: 27313400
- Serum amyloid A could represent a novel marker of primary unexplained recurrent early pregnancy loss because affected women exhibited elevated levels of this protein. PMID: 28099717
- The polymorphism of SAA1 is not associated with susceptibility and severity of Familial Mediterranean Fever in Egyptian children PMID: 27300189
- The findings identify SR-BII as a functional SAA receptor that mediates SAA uptake and contributes to its proinflammatory signaling via the MAPK-mediated signaling pathways. PMID: 28423002
- Correlate MEFV genotype and the SAA1 polymorphisms with the clinical manifestations of familial Mediterranean fever and the occurrence of amyloidosis in a large cohort of Armenian patients. PMID: 27791951
- Study found increased SAA concentration in patients with sarcoidosis. PMID: 26919159
- the detection of residues 76 and 77 of SAA (AA76) may alter the ability to diagnose AA amyloidosis. PMID: 27098620
- The results demonstrated that SAA upregulated Visfatin expression in cultured RAW264.7 macrophages and in the primary monocytes. PMID: 27006946
- Structure, function and SAA1 gene polymorphisms PMID: 26945629
- Serum Amyloid A induces inflammation, proliferation and cell death in activated hepatic stellate cells. PMID: 26937641
- Amyloid A overexpressed in renal cell carcinoma patients and can serve as a prognostic marker. PMID: 26750935
- incorporation of SAA into HDL preparations reduced antiinflammatory properties but not to the same extent as HDL from AgNO3-injected mice PMID: 26642365
- human SAA is possibly only expressed in a subset of septic patients; SAA induces HMGB1 release via TLR4 and RAGE receptors; SAA supplementation worsens the outcome of lethal endotoxemia PMID: 26052716
- The SAA1 rs12218 polymorphism was significantly more prevalent in ankylosing spondylitis patients with amyloidosis. PMID: 26300108
- Autocrine/paracrine and recombinant human SAA1 via TLR4 stimulate a proinflammatory phenotype that is both part of the early phase of osteogenic differentiation and the development of senescence. PMID: 26135899
- Serum amyloid A1alpha induces paracrine IL-8/CXCL8 via TLR2 and directly synergizes with this chemokine via CXCR2 and formyl peptide receptor 2 to recruit neutrophils. PMID: 26297794
- These functional properties set SAA apart from well-characterized inflammatory factors, such as LPS and TNF-alpha, suggesting that it may play a homeostatic role during the course of inflammation. PMID: 26130702
- The detailed analysis of the docking results points to the fact that the best serum amyloid A-Cystatin C (SAA-hCC) binding is achieved by the peptides inclined toward interacting via Lys90 and Arg 96 (with ffhCC Ser98 and Tyr102, respectively). PMID: 25736604
- Our results showed PCT as a valuable marker of bacterial infections in febrile patients. PCT was superior to CRP, IL-6 or SAA in the early identification of bacterial infection PMID: 25963492
- Mutations in genetic biomarker SAA1 gene related to amyloidosis processes may play a crucial role in chronic renal failure patients who require long-term hemodialysis. PMID: 25394530
- The relative abundance of the N-terminal arginine truncation of SAA1.1 is significantly decreased in diabetes and negatively correlates with measures of glycemic and lipid control. PMID: 25607823
- potential marker for detecting the activity of srcoidosis PMID: 25623898
- Genetic polymorphisms in SAA1 are associated with coronary artery disease in the Han and Uygur populations in Western China. PMID: 25656165
- High SAA serum level is associated with hepatocellular carcinoma. PMID: 25605163
- HDL3 subpopulations in ST segment elevation myocardial infarction were enriched 10 times in SAA patients. PMID: 26037829
- SAA has a role in activity of rheumatoid arthritis and risk of cardiovascular and renal involvement PMID: 25525305
- SR-B1 and p38 MAPK are involved in signaling pathway of serum amyloid A-induced angiogenesis in rheumatoid arthritis. PMID: 25932604
- Although SAA concentrations were elevated in the sera, there was no significant difference in these concentrations between familial Mediterranean fever patients and rheumatoid arthritis patients. PMID: 25240611
- Zn deficiency enhances the acute phase response and particularly the JAK-STAT3 pathway, resulting in increased serum amyloid A production. PMID: 24732911
- Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection. PMID: 25073702
- Data suggest that serum amyloid A (SAA) is a candidate for diabetic kidney disease therapeutic and biomarker discovery. PMID: 25531567
- The CSF biomarker amyloid 1-42 is important and useful as part of the diagnostic procedure for detecting AD and other dementia in elderly patients displaying psychotic symptoms. PMID: 23597931
- homozygous SAA1.5/1.5 genotype appears to be a recessive susceptibility gene, which has lost the antiangiogenic function, whereas SAA1.1 and SAA1.3 are the dominant alleles of the tumor suppressor phenotype. PMID: 24608426
- keratinocyte-derived SAA triggers a key inflammatory mediator, IL-1beta, via NLRP3 inflammasome activation, providing new potential targets for the treatment of this chronic skin disease. PMID: 25231464
- SAA1 gene expression in COPD patients is responsible for the secretion of this molecule in different cell types. PMID: 24884805
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相關(guān)疾?。?/div>Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.亞細(xì)胞定位:Secreted.蛋白家族:SAA family組織特異性:Expressed by the liver; secreted in plasma (at protein level).數(shù)據(jù)庫鏈接:
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