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SCGB2A1 Antibody, Biotin conjugated

  • 中文名稱：
    SCGB2A1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA020816LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SCGB2A1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SCGB2A1
  • 別名：
    Lacryglobin antibody; LIPHC antibody; Lipophilin C antibody; Lipophilin-C antibody; LPHC antibody; LPNC antibody; Mammaglobin 2 antibody; Mammaglobin-2 antibody; Mammaglobin-B antibody; MGB2 antibody; MGC71973 antibody; Scgb2a1 antibody; Secretoglobin family 2A member 1 antibody; Secretoglobin; family 2A; member 1 antibody; SG2A1_HUMAN antibody; UGB3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Mammaglobin-B protein (19-95AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產品評價

靶點詳情

  • 功能：
    May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.
  • 基因功能參考文獻：
    1. The expression of HOXB13, IL17BR, and mammaglobin 1 in sentinel lymph nodes predict the outcome of primary breast cancer patients. PMID: 29729704
    2. novel marker GATA3 stains a significantly higher proportion of both primary and metastatic breast carcinomas than GCDFP15 or mammaglobin with stronger and more diffuse staining, helpful in cases with small tissue samples PMID: 25906123
    3. The commonly used breast carcinoma biomarkers vary in their prognostic implications. GCDFP-15 independently indicated a favourable prognosis. GATA-3 and MGB were not associated with outcome. PMID: 25425335
    4. Results indicate that the quantitative analysis of h-MAM mRNA is a useful tool for detecting CTCs in breast cancer patients. PMID: 24706379
    5. Results indicated that SCGB2A1 represented a novel, prognostic factor for colorectal cancer, and its expression correlated with chemoresistance, radioresistance and cancer cell stemness. PMID: 24585249
    6. The data indicate that MGB1, MGB2 and LIPB mRNAs are expressed at low levels in human tissues but basal expression is upregulated in ovarian cancer. PMID: 24603286
    7. SCGB2A1 is a top differentially expressed gene in all major histological types of ovarian cancers. PMID: 23807163
    8. MGB has the highest expression in HER2-overexpressing breast cancers and may be a potentially useful marker for this subtype. PMID: 23332923
    9. Data show that plasma mammaglobin mRNA alone or in combination with CA15.3 (CD227) may be used as a valuable noninvasive approach for the diagnosis and the detection of metastasis in breast cancer at the time of diagnosis. PMID: 20306663
    10. The mammaglobin/lipophilin B complex is a promising diagnostic marker for breast cancer. PMID: 12022875
    11. MGB2 markers may be useful for identifying micrometastases in sentinel lymph nodes of breast cancer patients. PMID: 15151203
    12. SCGB 2A1 represents a new class of androgen target genes that are purely under indirect AR control mediated by DNA-bound Sp factors. PMID: 16020486
    13. Results indicate that mammaglobin, as measured by the ELISA, holds significant promise for breast cancer screening with the realistic potential to impact management of this disease. PMID: 16166429
    14. MGB-2 is highly expressed in endometrioid endometrial cancer [EEC], particularly in well- and moderately differentiated tumors, and may represent a novel molecular marker for EEC PMID: 18021217
    15. Expression levels of mammaglobins A and B in nasal polyps are not different between patients with and without AR PMID: 18416968
    16. MGB-2 expression characterizes less aggressive forms of EOC and is correlated with a favorable outcome PMID: 19635143

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Secretoglobin family, Lipophilin subfamily
  • 組織特異性：
    Expressed in thymus, trachea, kidney, steroid responsive tissues (prostate, testis, uterus, breast and ovary) and salivary gland.
  • 數(shù)據庫鏈接：

    HGNC: 7051

    OMIM: 604398

    KEGG: hsa:4246

    STRING: 9606.ENSP00000244930

    UniGene: Hs.97644