SCN3A Antibody
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中文名稱:SCN3A兔多克隆抗體
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貨號(hào):CSB-PA885761ESR1HU
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規(guī)格:¥440
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促銷:
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圖片:
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱:Rabbit anti-Homo sapiens (Human) SCN3A Polyclonal antibody
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Uniprot No.:
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基因名:SCN3A
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別名:brain III voltage-gated sodium channel antibody; NAC3 antibody; Nav1.3 antibody; SCN3A antibody; SCN3A_HUMAN antibody; Sodium channel protein brain III subunit alpha antibody; Sodium channel protein type 3 subunit alpha antibody; Sodium channel protein type III subunit alpha antibody; Sodium channel protein, brain III subunit alpha antibody; sodium channel, brain type III, alpha subunit antibody; sodium channel, neuronal type III, alpha subunit antibody; sodium channel, voltage-gated, type III, alpha polypeptide antibody; sodium channel, voltage-gated, type III, alpha subunit antibody; Voltage gated sodium channel subtype III antibody; Voltage gated sodium channel subunit alpha Nav1.3 antibody; Voltage-gated sodium channel subtype III antibody; Voltage-gated sodium channel subunit alpha Nav1.3 antibody
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宿主:Rabbit
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反應(yīng)種屬:Human
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免疫原:Recombinant Human Sodium channel protein type 3 subunit alpha protein (274-400AA)
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:Antigen Affinity Purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA, IHC
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推薦稀釋比:
Application Recommended Dilution IHC 1:20-1:200 -
Protocols:
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儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. May contribute to the regulation of serotonin/5-hydroxytryptamine release by enterochromaffin cells. In pancreatic endocrine cells, required for both glucagon and glucose-induced insulin secretion.
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基因功能參考文獻(xiàn):
- SCN3A is involved in development of the human brain and oral motor development. When SCN3A is mutated, patients present with polymicrogyria and speech deficits. PMID: 30146301
- Novel de novo variant SCN3A-L247P was demonstrated to cause a defect in trafficking, which would be predicted to functionally reduce SCN3A activity. Consistent with the clinical observations, Scn3a+/Hyp mice display increased seizure susceptibility, hypoactivity, and impaired motor learning. PMID: 28235671
- sodium channel currents in oocytes expressing either wild-type or mutant (A4V) SOD1 protein PMID: 27072680
- Discovery of a common biophysical defect among variants identified in unrelated pediatric epilepsy patients suggests that SCN3A may contribute to neuronal hyperexcitability and epilepsy. PMID: 24157691
- Upregulation of Nav1.3 protein and a specific cellular distribution of Nav1.3 proteins in focal cortical dysplasia type IIb(FCDIIb) lesion tissue samples suggest that Nav1.3 may be involved in the generation of epileptic activity in FCDIIb. PMID: 22494998
- Deletions in SCN3A gene is associated with autistic features and developmental delay. PMID: 20346423
- In trigeminal neuralgia (TN) there is a reduction in the expression of Nav1.7 and an increase in the expression of Nav1.3, Nav1.8 expression not significantly different; TN can be, at least in part, a channelopathy. PMID: 19699781
- in autism families, two polymorphic coding variants of SCN3A are described PMID: 12610651
- Characterization of 5' untranslated regions SCN3A, and identification of cis-conserved noncoding sequences. PMID: 17544618
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亞細(xì)胞定位:Cell membrane; Multi-pass membrane protein.
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蛋白家族:Sodium channel (TC 1.A.1.10) family, Nav1.3/SCN3A subfamily
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組織特異性:Expressed in enterochromaffin cells in both colon and small bowel (at protein level).
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數(shù)據(jù)庫鏈接:
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