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SDHAF2 Antibody, Biotin conjugated

  • 中文名稱(chēng)：
    SDHAF2兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA885749LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) SDHAF2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SDHAF2
  • 別名：
    Chromosome 11 open reading frame 79 antibody; FLJ20487 antibody; hSDH5 antibody; mitochondrial antibody; Paraganglioma or familial glomus tumors 2 antibody; PGL2 antibody; SDH assembly factor 2 antibody; SDH5 antibody; Sdhaf2 antibody; SDHF2_HUMAN antibody; Succinate dehydrogenase assembly factor 2, mitochondrial antibody; Succinate dehydrogenase subunit 5 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Succinate dehydrogenase assembly factor 2, mitochondrial protein (30-166AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.
  • 基因功能參考文獻(xiàn)：
    1. Loss of SDHAF2 gene is associated with paragangliomas. PMID: 28099933
    2. The SDHA, TMEM127, MAX, and SDHAF2 genes contribute to hereditary pheochromocytoma and paraganglioma. PMID: 28384794
    3. data show that SDHA flavination is independent of SDHAF2 in breast cancer cells, employing an alternative mechanism. PMID: 27587393
    4. FAD interacts noncovalently with SDHA in the absence of SDH5 PMID: 27296776
    5. Autosomal dominant susceptibility for Paraganglioma is modified by imprinting and mutations in the SDHAF2 gene cause Paragangliomas only when the mutation is inherited from father. PMID: 24973967
    6. Loss of heterozygosity was found in more than 50 % of the von Hippel-Lindau-associated pheochromocytomas, and was correlated with a significant decrease (p < 0.05) in both SDHAF2 and SDHD mRNA expression, which may be suggestive of a pathogenic role. PMID: 24322175
    7. New mutation found in SDHAF2 gene in pheochromocytoma/paraganglioma patients. PMID: 24712571
    8. Data indicate that SDH5 is protected from mitochondrial LON (LONM)-mediated degradation in mitochondria by its stable interaction with SDHA, a state that is dysregulated in hereditary paraganglioma 2 (PGL2). PMID: 24414418
    9. Data indicate that succinate dehydrogenase 5 (SDH5) functions as a critical protein in regulating epithelial-mesenchymal transition (EMT) by modulating the glycogen synthase kinase (GSK)-3beta-beta-catenin signaling pathway. PMID: 23983127
    10. Studies indicate that mutations in the mitochondrial complex II structural subunit genes SDHB, SDHC and SDHD and the regulatory subunit gene SDHAF2 in many paraganglioma families. PMID: 23291190
    11. Studies indicate that an array of tumor syndromes caused by complex II-associated mutations in genes SDHA, SDHB, SDHC, SDHD, SDHAF1 and SDHAF2 have been identified over a decade. PMID: 23174333
    12. Studies indicate that the flavinylation factor Sdh5 (SDHAF2) provided insight into the possible mechanism associated with Sdh1 (SDHA) flavinylation. PMID: 23380393
    13. We established the SDHAF2 mutation status of PGL2 family members PMID: 21224366
    14. Somatic mutations of the SDHAF2 tumor suppressor gene are unlikely to frequently contribute to parathyroid tumor development in sporadic primary hyperparathyroidism. PMID: 20972721
    15. germline loss-of-function mutations in the SDH5 gene segregate with disease in a family with hereditary paraganglioma PMID: 19628817

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  • 相關(guān)疾?。?/div>
    Paragangliomas 2 (PGL2)
  • 亞細(xì)胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    SDHAF2 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 26034

    OMIM: 601650

    KEGG: hsa:54949

    STRING: 9606.ENSP00000301761

    UniGene: Hs.313247