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SEC31A Antibody, FITC conjugated

  • 中文名稱：
    SEC31A兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA020954LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SEC31A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    SEC31A antibody; KIAA0905 antibody; SEC31L1 antibody; HSPC275 antibody; HSPC334 antibody; Protein transport protein Sec31A antibody; ABP125 antibody; ABP130 antibody; SEC31-like protein 1 antibody; SEC31-related protein A antibody; Web1-like protein antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Protein transport protein Sec31A protein (335-503AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
  • 基因功能參考文獻：
    1. USP8 deubiquitinates Sec31A and inhibits the formation of large COPII carriers, thereby suppressing collagen IV secretion. PMID: 29604273
    2. findings suggest that AnxA11 maintains architectural and functional features of the ERES by coordinating with ALG-2 to stabilize Sec31A at the ERES. PMID: 25540196
    3. These results suggest that Sec31 phosphorylation by CK2 controls the duration of COPII vesicle formation, which regulates ER-to-Golgi trafficking. PMID: 23349870
    4. efficient COPII-dependent secretion, notably assembly of Sec13-Sec31, is required to drive epithelial morphogenesis in both two- and three-dimensional cultures PMID: 22331354
    5. SEC31A-ALK fusions are recurrent in ALK-positive large B-cell lymphomas. PMID: 21109691
    6. t(4;9)(q21;p24) leads to a novel SEC31A-JAK2 fusion in Hodgkin lymphoma PMID: 21325169
    7. Genomic PCR and subsequent sequencing showed that the breakpoints were located in intron 23 of SEC31L1 and intron 20 of anaplastic lymphoma kinase PMID: 16161041
    8. three-dimensional reconstruction of Sec13/31 cages at 30 A resolution using cryo-electron microscopy and single particle analysis PMID: 16407955
    9. In vitro GST pull down analysis demonstrated that ALG-2 and its alternatively spliced isoform interact with the COPII component Sec31A in a Ca2+-dependent manner, and a biotin-labeled ALG-2 overlay assay revealed direct binding of ALG-2 to Sec31A. PMID: 17196169
    10. The Sec31 active fragment is accommodated in a binding groove supported in part by Sec23 residue Phe380. PMID: 17981133

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  • 相關(guān)疾?。?/div>
    A chromosomal aberration involving SEC31A is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;4)(p23;q21) with ALK.
  • 亞細胞定位：
    Cytoplasm. Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein. Cytoplasm, cytosol.
  • 蛋白家族：
    WD repeat SEC31 family
  • 組織特異性：
    Abundantly and ubiquitously expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17052

    OMIM: 610257

    KEGG: hsa:22872

    STRING: 9606.ENSP00000347329

    UniGene: Hs.370024