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SELENOW Antibody, FITC conjugated

  • 中文名稱：
    SELENOW兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA021034LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SELENOW Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SELENOW
  • 別名：
    SELENOW antibody; SELW antibody; SEPW1 antibody; Selenoprotein W antibody; SelW antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Selenoprotein W protein (11-86AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency.
  • 基因功能參考文獻：
    1. The SS concentrations that lead to a decrease in the viability of human prostate adenocarcinoma cells (line Du-145) have been selected, and the effect of sodium selenite on the expression of mRNA of the SELV, SELW, and TGR selenocysteine proteins in these cells has been analyzed. PMID: 29989584
    2. SelW may have a regulatory function in redox cell signaling by interacting with 14-3-3 protein. PMID: 26474786
    3. Suppression of EGFR ubiquitination by SEPW1 may be related to the putative increase in cancer risk associated with high selenium intakes. PMID: 25721765
    4. In response to selenium compounds, SepW1 synthesis increased at the protein and the mRNA levels. PMID: 23830627
    5. p53 was increased in SEPW1 silenced cells and was inversely correlated with SEPW1 mRNA in cell lines with altered SEPW1 expression. PMID: 21866568
    6. The present work shows that SEPW1 facilitates the G1 to S-phase transition by down-regulating expression of the cyclin-dependent kinase inhibitor p21 PMID: 21875573
    7. The gene lacks canonical TATA and CAAT boxes, but has numerous Sp1 consensus binding sites upstream of multiple transcription start sites. SEPW1 is expressed in all of the 22 tissues assayed, and shows highest expression in skeletal muscle and heart. PMID: 12818432
    8. SelW expression in the colon is highly sensitive to Se-depletion PMID: 15670848
    9. SeW is the novel molecular target of MeHg in human neuronal cells and down-regulation of this selenoenzyme by MeHg is dependent not on generation of ROS but on depletion of GSH. PMID: 15823556
    10. SEPW1 mRNA levels were maximal during G1-phase, dropped after the G1/S transition and increased again after G2/M-phase. PMID: 19387567
    11. The small interfering RNA knockdown of BNIP3, IER3, and SEPW1 genes affected critical multiple myeloma endothelial cell functions correlated with the overangiogenic phenotype PMID: 19690192

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    SelWTH family, Selenoprotein W subfamily
  • 組織特異性：
    Ubiquitously expressed with highest levels in skeletal muscle and heart, moderate levels in brain, spinal cord, thyroid, spleen, prostate, ovary, small intestine and colon, and lowest levels in liver and lymph node.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10752

    OMIM: 603235

    KEGG: hsa:6415

    STRING: 9606.ENSP00000422644

    UniGene: Hs.631549