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SENP7 Antibody, Biotin conjugated

  • 中文名稱：
    SENP7兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA805340LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SENP7 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SENP7
  • 別名：
    KIAA1707 antibody; Senp7 antibody; SENP7_HUMAN antibody; Sentrin specific protease antibody; Sentrin-specific protease 7 antibody; Sentrin/SUMO-specific protease SENP7 antibody; SSP2 antibody; SUMO 1 specific protease 2 antibody; SUMO specific protease antibody; SUMO-1-specific protease 2 antibody; SUMO1/sentrin specific peptidase 7 antibody; SUSP2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Sentrin-specific protease 7 protein (128-366AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.
  • 基因功能參考文獻：
    1. SPOP inhibits hepatocellular carcinoma (HCC) cell metastasis via ubiquitin-dependent SENP7 proteolysis and may thus serve as a new opinion for the prevention of HCC metastasis. PMID: 29777712
    2. c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4 PMID: 25895136
    3. deSUMOylation by SENP7 is required to promote a permissive chromatin environment for DNA repair. PMID: 24018422
    4. differential splicing of the SENP7 regulates either tumor suppression or progression PMID: 23045645
    5. Loop 1 insertion in SENP6 and SENP7 as a platform to discriminate between SUMO1 and SUMO2/3 isoforms in this subclass of the SUMO protease family. PMID: 21878624
    6. SENP6 and SENP7 exhibit lower rates for processing pre-SUMO1, pre-SUMO2, or pre-SUMO3 in comparison with SENP2 PMID: 18799455

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  • 蛋白家族：
    Peptidase C48 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30402

    OMIM: 612846

    KEGG: hsa:57337

    STRING: 9606.ENSP00000377655

    UniGene: Hs.529551