SIX6 Antibody
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中文名稱:SIX6兔多克隆抗體
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貨號:CSB-PA004096
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規(guī)格:¥880
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圖片:
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:SIX6
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別名:Homeobox protein SIX6 antibody; Homeodomain protein OPTX2 antibody; MCOPCT 2 antibody; MCOPCT2 antibody; Optic homeobox 2 antibody; OPTX 2 antibody; OPTX2 antibody; Sine oculis homeobox homolog 6 antibody; SIX 6 antibody; Six 9 antibody; SIX homeobox 6 antibody; Six6 antibody; SIX6_HUMAN antibody; Six9 antibody
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宿主:Rabbit
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反應(yīng)種屬:Human,Mouse,Rat
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免疫原:Synthesized peptide derived from the Internal region of Human Six3/6.
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
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抗體亞型:IgG
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純化方式:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:WB, IF, ELISA
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推薦稀釋比:
Application Recommended Dilution WB 1:500-1:2000 IF 1:200-1:1000 ELISA 1:20000 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:May be involved in eye development.
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基因功能參考文獻(xiàn):
- The results suggest that SIX6 influences different stages of RGC differentiation and their survival; therefore, alteration in SIX6 function due to the risk allele may lead to cellular and molecular abnormalities. PMID: 28792678
- We replicated the association of SNP rs10483727 in the SIX1/SIX6 locus with POAG in a Saudi cohort, suggesting its role in increasing susceptibility to Primary Open Angle Glaucoma . PMID: 29190129
- Among 8 SNPs in 3 loci that showed at least nominal association (P < 5.00E-02) in the primary cohort, a representative SNP for each loci (rs2157719 for CDKN2B-AS1, rs33912345 for SIX6, and rs9913911 for GAS7) were selected PMID: 29261660
- elevated expressions of SIX2, SIX4, and SIX6 predicted poor overall survival (OS) in NSCLC and poor relapse-free survival (RFS) in lung adenocarcinoma PMID: 27821176
- study replicated the association of POAG with two SNPs at the SIX1-SIX6 locus and demonstrated that SNPs, rs10483727 and rs33912345, are significantly associated with POAG, especially with NTG in patients aged above 40 years PMID: 27260188
- Six1 regulates p53 via a dual mechanism involving upregulation of microRNA-27a and downregulation of RPL26. PMID: 26687066
- Single nucleotide polymorphism in SIX6 gene is associated with primary open angle glaucoma. PMID: 25798827
- SIX6 and/or intraocular pressure promotes primary open-angle glaucoma by directly increasing p16INK4a expression. PMID: 26365380
- we report a homozygous missense mutation of SIX6 associated with a unique eye phenotype characterized by optic disc anomalies, macular atrophy, and coloboma of the iris and chorioretina. PMID: 24702266
- Nonglaucomatous individuals with the SIX6 missense variant have reduced RNFL thickness in regions known to be particularly affected in those with glaucoma. PMID: 25537207
- Our results, in combination with previous SIX6 work, lead us to hypothesize that SIX6 risk variants disrupt the development of the neural retina, leading to a reduced number of retinal ganglion cells. PMID: 24875647
- Our findings in humans and zebrafish suggest a functional involvement of six6b in early eye development, and open new insights into the genetic architecture of POAG. PMID: 24150847
- No evidence was found that SIX6 mutations underlie human congenital structural eye malformations. PMID: 15505031
- Six6 and Six2 differ in their DNA-binding mechanisms and in the consequences of their interaction with protein tyrosine phosphatase Eyes Absent in Six2/6-DNA-binding ability. PMID: 18293925
- BOR and OAVS features are associated with duplication of SIX1, SIX6 and OTX2 resulting from a complex chromosomal rearrangement. PMID: 18666230
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相關(guān)疾?。?/div>Optic disk anomalies with retinal and/or macular dystrophy (ODRMD)亞細(xì)胞定位:Nucleus.蛋白家族:SIX/Sine oculis homeobox family組織特異性:Expressed in the developing and adult retina. Also expressed in the hypothalamic and the pituitary regions.數(shù)據(jù)庫鏈接:
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