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  4. SKIL Antibody

SKIL Antibody

  • 中文名稱：
    SKIL兔多克隆抗體
  • 貨號(hào)：
    CSB-PA932063
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA932063(SKIL Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA932063(SKIL Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Huvec cells, Primary antibody: CSB-PA932063(SKIL Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    OTTHUMP00000213557 antibody; OTTHUMP00000213591 antibody; OTTHUMP00000213592 antibody; OTTHUMP00000213595 antibody; SKI like antibody; SKI like oncogene antibody; Ski like protein antibody; SKI like proto oncogene antibody; Ski related oncogene antibody; Ski related oncogene snoN antibody; Ski related protein antibody; Ski-like protein antibody; Ski-related oncogene antibody; Ski-related protein antibody; SKIL antibody; SKIL_HUMAN antibody; SNO antibody; SnoA antibody; SnoI antibody; SnoN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human SKIL
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:30-1:150
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May have regulatory role in cell division or differentiation in response to extracellular signals.
  • 基因功能參考文獻(xiàn)：
    1. It is a critical negative regulator of TGF-beta1/Smad signal pathway, involving in tubule epithelial-mesenchymal transition (EMT), extracellular matrix (ECM) accumulation, and tubulointerstitial fibrosis. PMID: 28707079
    2. signal transducer and activator of transcription (Stat)3 represses Smad3 in synergy with the potent negative regulators of TGF-beta signaling, c-Ski and SnoN, whereby renders gefitinib-sensitive HCC827 cells resistant PMID: 28115165
    3. SnoN interacts with multiple components of the Hippo pathway to inhibit the binding of Lats2 to TAZ and the subsequent phosphorylation of TAZ, leading to TAZ stabilization. PMID: 27237790
    4. suggest that SnoN suppresses TGF-betainduced epithelial-mesenchymal transition and invasion of bladder cancer cells in a TIF1gammadependent manner PMID: 27430247
    5. the findings of this study demonstrate that the downregulation of SnoN expression in hRPTECs under high-glucose conditions is mediated by the increased expression of Smurf2 through the TGF-b1/Smad signaling pathway. PMID: 26743567
    6. RNAi-mediated downregulation of SnoN effectively inhibited proliferation and enhanced apoptosis of pancreatic cells. PMID: 25907906
    7. SKIL knockdown led to growth arrest in PC-3 and LNCaP cell line models of prostate cancer, and its overexpression led to increased invasiveness in RWPE-1 cells. PMID: 25749039
    8. Whole exome sequencing of the blood of the patient and both parents revealed a de novo germline SKIL mutation in the child that was not present in either parent PMID: 25464936
    9. Data indicate that tripartite motif containing 33 protein TIF1gamma promotes sumoylation of SKI-like proto-oncogene protein SnoN1 and regulates epithelial-mesenchymal transition (EMT). PMID: 25059663
    10. The results indicate that protein ubiquitination promotes megakaryopoiesis via degrading SnoN, an inhibitor of CD61 expression, strengths the roles of ubiquitination in cellular differentiation. PMID: 24637302
    11. SnoNspecific siRNA is capable of effectively inhibiting the expression of SnoN in human HepG2 cells, and the downregulation of SnoN expression induces growth inhibition and apoptosis PMID: 23446947
    12. these studies identify TLOC1 and SKIL as driver genes at 3q26 and more broadly suggest that cooperating genes may be coamplified in other regions with somatic copy number gain. PMID: 23764425
    13. High SnoN expression is associated with metastasis in breast cancer. PMID: 23832742
    14. Phospholipid Scramblase 1, an interferon-regulated gene located at 3q23, is regulated by SnoN/SkiL in ovarian cancer cells. PMID: 23621864
    15. These data strongly suggest that SnoN can function as a tumor suppressor at early stages of tumorigenesis in human cancer tissues. PMID: 23418461
    16. These results support our observation that cancer tissues have lower expression levels of SnoN, miR-720, and miR-1274A compared to adjacent normal tissues from esophageal squamous cell carcinoma patients. PMID: 23154181
    17. Data suggest that SKIL expression is modulated by antineoplastic agents and may be involved in drug resistance in ovarian carcinoma; up-regulation of SKIL expression by arsenic trioxide and reduction of apoptosis involves activation of PI3K pathway. PMID: 23178716
    18. SNON predominantly associates with SMAD2 at the promoters of primitive streak (PS) and early DE marker genes PMID: 23154981
    19. the SNON-SMAD4 complex negatively regulated basal SKIL gene expression through binding the promoter and recruiting histone deacetylases PMID: 22674574
    20. SnoN mediates a negative feedback mechanism evoked by TGF-beta to inhibit BMP signaling and, subsequently, hypertrophic maturation of chondrocytes. PMID: 22767605
    21. SnoN may have broad functions in the embryonic development and tissue morphogenesis [Review] PMID: 22710172
    22. analysis of SnoN signaling in proliferating cells and postmitotic neurons [review] PMID: 22710173
    23. SnoN level promotes ERalpha signaling and possibly breast cancer progression. PMID: 22227247
    24. The flexibility in the putative protein binding groove enables SnoN to recognize multiple interaction partners. PMID: 20957027
    25. Regulation of TGF-beta-co-repressor (SnoN) is greatly affected suggesting that SnoN as a cardinal player in cholestasis-induced fibrogenesis. PMID: 19889106
    26. The endogenous SnoN plays a role in regulating ADAM12 expression in response to TGFbeta1. PMID: 20457602
    27. SnoN elevation is associated with mammary gland branching morphogenesis, postlactational involution, and mammary tumorigenesis. PMID: 20460516
    28. BMP-7 prevents TGF-beta-mediated loss of the transcriptional repressor SnoN and hence specifically limits Smad3 DNA binding. PMID: 20093492
    29. Inhibition of Smad signaling may be achieved at the transcriptional level through c-Ski/receptor-Smad/co-mediator Smad4 interactions--REVIEW PMID: 19898560
    30. SnoN acts as a positive mediator of TGF-beta-induced transcription and cell cycle arrest in lung epithelial cells PMID: 15677458
    31. Sno expression was identified as an important mechanism to shut off antiproliferative TGF-beta signaling in malignant melanoma PMID: 15809735
    32. mechanism of regulation of TGF-beta signaling via differential subcellular localization of SnoN PMID: 16109768
    33. A novel role of SnoN in the transforming activity of TGF-beta in fibroblasts was demonstrated. PMID: 16314499
    34. SnoN also seems to regulate negatively the TGF-beta-responsive SMAD, mothers against DPP homolog 7 gene by binding and repressing its promoter in a similar way to Ski PMID: 16442497
    35. SnoN is directly regulated by sumoylation leading to the enhancement of the ability of SnoN to repress transcription in a promoter-specific manner PMID: 16966324
    36. snoN protein has both oncogenic and tumor suppressive properties in colorectal tumorigenesis. PMID: 17062133
    37. SnoN plays both pro-tumorigenic and antitumorigenic roles at different stages of mammalian malignant progression PMID: 17074815
    38. Arkadia induces degradation of SnoN and c-Ski in addition to Smad7. PMID: 17510063
    39. Results show that Arkadia specifically activates transcription via Smad3/Smad4 binding sites by inducing degradation of the transcriptional repressor SnoN. PMID: 17591695
    40. CREB activation, in concert with Sp1, constitutes a molecular switch that confers the cell type-specific induction of SnoN in response to HGF stimulation PMID: 17625116
    41. SnoN overexpression is associated with depth of invasion and recurrence in patients with esophageal squamous cell carcinoma. PMID: 18612694
    42. Data show that dominant-negative transforming growth factor beta type II receptor decreases matrix metalloproteinase 2 in hepatic stellate cells, and upregulates SKI-like oncogene, which antagonizes TGF-beta signaling. PMID: 19189315
    43. results implicate SnoN levels in multiple roles during ovarian carcinogenesis: promoting cellular proliferation in ovarian cancer cells and as a positive mediator of cell cycle arrest and senescence in non-transformed ovarian epithelial cells PMID: 19383336
    44. SnoN is involved in differentiation in normal skin and benign and nonmetastatic skin tumors, but plays a proto-oncogenic role in undifferentiated squamous cell carcinoma PMID: 19538364

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  • 蛋白家族：
    SKI family
  • 組織特異性：
    Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 10897

    OMIM: 165340

    KEGG: hsa:6498

    STRING: 9606.ENSP00000259119

    UniGene: Hs.536655