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SLC16A7 Antibody

  • 中文名稱：
    SLC16A7兔多克隆抗體
  • 貨號：
    CSB-PA119717
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA119717(SLC16A7 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA119717(SLC16A7 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10+12%SDS-PAGE, Lysate: 30 μg, Lane: A549 cells, Primary antibody: CSB-PA119717(SLC16A7 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    SLC16A7
  • 別名：
    MCT 2 antibody; MCT antibody; Monocarboxylate transporter 2 antibody; MonocarboxylateTransporter 2 antibody; MOT2 antibody; MOT2_HUMAN antibody; SLC16A7 antibody; Solute carrier family 16 (monocarboxylate transporter), member 7 antibody; Solute carrier family 16 member 7 antibody; Solute carrier Family 16 Monocarboxylic Acid Transporters Member 7 antibody; Solute carrier family 16, member 7 (monocarboxylic acid transporter 2) antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human SLC16A7
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:15-1:50
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.
  • 基因功能參考文獻：
    1. Adipocytes promote malignant growth of breast tumors with MCT2 expression via beta-hydroxybutyrate. PMID: 28281525
    2. SLC16A7 (MCT2) epigenetic regulation results in protein over-expression, affecting signalling and cellular phenotypes in prostate cancer PMID: 26035357
    3. Data suggest that monocarboxylate transporter 2 (MCT2) at peroxisomes is related to an increase in beta-oxidation levels which may be crucial for malignant transformation. PMID: 25639644
    4. This study identified that CGPs was found to significantly correlate with the differential expression and methylation of genes encoding solute carrier family 16, member 7. PMID: 25243493
    5. Our findings suggest that SNPs in MCT1 and MCT2 genes may affect clinical outcomes and can be used to predict the response to adjuvant chemotherapy in NSCLC patients who received surgical treatment once validated in future study. PMID: 25578492
    6. SNPs in MCT1 and MCT2 genes may affect clinical outcomes and can be used to predict the response to adjuvant chemotherapy in CRC patients who received surgical treatment. PMID: 25492048
    7. MCT2-3' UTR SNP (+2626 G > A) had a strong association with oligoasthenoteratozoospermia. PMID: 24799634
    8. this study provided evidence for the presence of MCT2 in prostate cancer, selectively labeling malignant glands. PMID: 23192371
    9. The monocarboxylate transporter 2 (MCT2) protein was tumor-selectively expressed in human colorectal malignancies and knockdown of MCT2 induces mitochondrial dysfunction, cell-cycle arrest, and senescence. PMID: 22964484
    10. Light microscopic immunohistochemistry revealed significantly less perivascular MCT2 immunoreactivity in the hippocampal formation in medial temporal lobe epilepsy than in non-MTLE patients PMID: 22535546
    11. data suggest that extracellular membrane-bound CAIV, but not cytosolic CAII, augments transport activity of MCT2 in a non-catalytic manner, possibly by facilitating a proton pathway other than His-88 PMID: 21680735
    12. Ocular absorption of monocarboxylic acid drugs may be enhanced by MCT transporter SLC16A7, and the absorption route provided by this transporter may be utilized to improve the bioavailability of topically applied ophthalmic drugs. PMID: 20035863
    13. MCT2 immunoreactivity was noted in astrocytic cell bodies from week 19 and spread subsequently to the astrocyte end-feet in contact with blood vessels of visual cortex. PMID: 14757520
    14. Colorectal neoplasms showed a loss of expression of MCT2 in plasma membranes. PMID: 18188595
    15. These data demonstrate neuronal MCT2 expression in human, but since a portion of it exhibits a distinct synaptic localization, it further supports a putative role for MCT2 in adjustment of energy supply to levels of activity. PMID: 18598673

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator superfamily, Monocarboxylate porter (TC 2.A.1.13) family
  • 組織特異性：
    Detected in heart and in blood lymphocytes and monocytes (at protein level). High expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain and Leukocyte. Restricted expression in normal tissues, but widely expressed
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10928

    OMIM: 603654

    KEGG: hsa:9194

    STRING: 9606.ENSP00000261187

    UniGene: Hs.439643