SLC26A2 Antibody, HRP conjugated
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中文名稱(chēng):SLC26A2兔多克隆抗體, HRP偶聯(lián)
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貨號(hào):CSB-PA021525LB01HU
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規(guī)格:¥880
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱(chēng):Rabbit anti-Homo sapiens (Human) SLC26A2 Polyclonal antibody
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Uniprot No.:
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基因名:SLC26A2
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別名:SLC26A2 antibody; DTD antibody; DTDST antibody; Sulfate transporter antibody; Diastrophic dysplasia protein antibody; Solute carrier family 26 member 2 antibody
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宿主:Rabbit
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反應(yīng)種屬:Human
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免疫原:Recombinant Human Sulfate transporter protein (614-739AA)
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:HRP
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克隆類(lèi)型:Polyclonal
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抗體亞型:IgG
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純化方式:>95%, Protein G purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA
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Protocols:
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儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Sulfate transporter. May play a role in endochondral bone formation.
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基因功能參考文獻(xiàn):
- Two heterozygous mutations in SLC26A2 mutations occur in a three-generational family with cases of multiple epiphyseal dysplasias. PMID: 29024831
- Results show that SLC26A2 expression is high in numerous tumor types and, provide evidence that it downregulates the TRAIL receptors, DR4 and DR5 which confers resistance to TRAIL. PMID: 28108622
- slc26a2 is to be a critical otic gene whose dysfunction may induce hearing impairment PMID: 26375458
- findings provide the first identification of autosomal dominant SLC26A2 mutations in patients with dysplastic spondylolysis, suggesting a new clinical entity in the pathogenesis of chondrodysplasia involving lumbosacral spine PMID: 26077908
- Diastrophic dysplasia sulfate transporter (SLC26A2) is expressed in the adrenal cortex and regulates aldosterone secretion. PMID: 24591336
- Up-regulation of SLC26A2 is associated with colorectal cancer. PMID: 24222123
- A compound heterozygote SLC26A2 mutation is associated with robin sequence, mild limbs shortness, accelerated carpal ossification, and multiple epiphysial dysplasia PMID: 23840040
- SLC13A4 and SLC26A2 were the most abundant sulfate transporter mRNAs, which localized to syncytiotrophoblast and cytotrophoblast cells, respectively. PMID: 23453247
- 73% of autosomal-recessive multiple epiphyseal dysplasia patients were either homozygous, or compound heterozygous, for SLC26A2 mutations. PMID: 21922596
- Solute carrier family 26 member a2 (Slc26a2) protein functions as an electroneutral SOFormula/OH-/Cl- exchanger regulated b PMID: 22190686
- Mutations in the SLC26A2 gene causes diastrophic dysplasia. PMID: 21155763
- Analysis suggests that, while the DTDST family of disorders contains at least seven different conditions, gene mutations appear to cause a phenotypic continuum. DTDST genotype alone is an imperfect predictor of clinical severity along this continuum. PMID: 21077202
- New intermediate phenotype between MED and DD caused by compound heterozygous mutations in the DTDST gene is reported. PMID: 21077204
- Characterize transport of oxalate and sulfate by human SLC26A2 and mouse Slc26a2 expressed in Xenopus oocytes. PMID: 20219950
- Diminished DTDST expression through epigenetic silencing is associated with colon cancer. PMID: 20460514
- DTDST function is crucial for the uptake of extracellular sulfate required for proteoglycan sulfation. PMID: 14692227
- The effects of sulfur availablility on proteoglycan sulfation in mice transgenic for a mutation of this gene are reported. PMID: 16719839
- This study found an association between single nucleotide polymorphisms of the SLC26A2 gene and juvenile idiopathic arthritis. PMID: 17393463
- DTDST is upregulated by dexamethasone stimulation of HT1080 fibrosarcoma cells and is required for fibronectin (FN) extracellular matrix deposition by these cells. PMID: 18056413
- A novel SLC26A2 mutation was found in all subjects, inserted by site-directed mutagenesis in a vector harbouring the SLC26A2 cDNA, and expressed in sulfate transport deficient Chinese hamster ovary (CHO) cells to measure sulfate uptake activity PMID: 18708426
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相關(guān)疾病:Diastrophic dysplasia (DTD); Achondrogenesis 1B (ACG1B); Atelosteogenesis 2 (AO2); Multiple epiphyseal dysplasia 4 (EDM4)
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亞細(xì)胞定位:Cell membrane; Multi-pass membrane protein.
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蛋白家族:SLC26A/SulP transporter (TC 2.A.53) family
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組織特異性:Ubiquitously expressed.
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