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SLC28A1 Antibody, FITC conjugated

  • 中文名稱：
    SLC28A1兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA021539LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SLC28A1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SLC28A1
  • 別名：
    CNT 1 antibody; CNT1 antibody; Concentrative nucleoside transporter 1 antibody; hCNT1 antibody; Na(+)/nucleoside cotransporter 1 antibody; S28A1_HUMAN antibody; SLC28A1 antibody; Sodium-coupled nucleoside transporter 1 antibody; Sodium/nucleoside cotransporter 1 antibody; solute carrier family 28 concentrative nucleoside transporter member 1 antibody; Solute carrier family 28 member 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Sodium/nucleoside cotransporter 1 protein (1-80AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Sodium-dependent and pyrimidine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). Transports uridine, cytidine, thymidine, and nucleoside-derived drugs. Transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine.
  • 基因功能參考文獻：
    1. Brazilian Amerindian ancestry compared to Asian, European, and African Genomes.SNPs within or proximal to CIITA (rs6498115), SMC6 (rs1834619), and KLHL29 (rs2288697) were most differentiated in the Amerindian-specific branch. SNPs in ADAMTS9 (rs7631391), DOCK2 (rs77594147), SLC28A1 (rs28649017), ARHGAP5 (rs7151991), and CIITA (rs45601437) in the Asian comparison. PMID: 28100790
    2. ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2. PMID: 25890497
    3. hCNT1 is a putative determinant for nucleoside analog chemoresistance in ovarian cancer. PMID: 25600708
    4. Human CNT1 fits the profile of a transceptor in a substrate translocation-independent manner and is likely to be relevant to tumor biology. PMID: 23722537
    5. MUC4 and hCNT1 as potential targets to ameliorate the response of pancreatic tumors to gemcitabine treatment. PMID: 22580602
    6. CNT1-mediated gemcitabine uptake shows a higher correlation with the CNT1 expression level than does ENT1-mediated uptake with ENT1 expression. PMID: 22644860
    7. Site-directed mutagenesis analysis reveals that only one sodium binding site is affected by a mutation; lack of serine546 residue is responsible for apparent loss of CNT1 function. PMID: 21998139
    8. our findings identify hCNT1 as a potential candidate to render drug-resistant pancreatic cancer cells amenable to chemotherapy. PMID: 21343396
    9. Two pyrimidine nucleoside analogs were potent inhibitors of CNT1, with negligible transportability and little apparent cytotoxicity, suggesting that they may have utility as cytoprotective agents. PMID: 20854794
    10. variability in hCNT1 and hENT1 expression in tumour and normal human breast tissue with different expression patterns related to patient prognosis and clinical outcome. PMID: 20734919
    11. Patients with low levels of hCNT1 achieved inferior clinical response. PMID: 19647871
    12. hCNT1 and hENT1 are expressed in polarized MDCK cells on the apical and basolateral membrane, respectively, allowing vectorial transport in both directions depending on the relative activity of each transporter for their substrates PMID: 12097333
    13. human pancreatic adenocarcinoma cells overexpress hENT1, although they retain the ability to express a functional hCNT1 transporter, an isoform that confers sensitivity to gemcitabine PMID: 14581375
    14. hCNT1 was by far the isoform whose expression was most frequently reduced or lost in the 3 types of gynecologic tumors analyzed.In uterine cervix tumors, the loss of expression of hCNT1 was significantly associated with the adenocarcinoma subtype. PMID: 15386342
    15. the N4 transport system is a naturally occurring variant of hCNT1, perhaps at the F316 position. Collectively, and G476 is important for correct membrane targeting, folding, and/or intracellular processing of hCNT1 PMID: 15456697
    16. We now report the effects of mutations in transmembrane helix 8 & demonstrate unique S353T- and L354V-induced changes in nucleoside specificity and cation coupling, respectively. PMID: 17279631
    17. In NSCLC and normal tissues expression of hENT1 and hCNT1 ranged from completely negative to high. PMID: 18600541
    18. We found a strong relationship between IHC staining of hCNT3 and clinical resistance to F-ara-A therapy in chronic lymphocytic leukemia. PMID: 18604194
    19. Report expression and hepatobiliary transport characteristics of CNT1 in sandwich-cultured human hepatocytes. PMID: 18635603
    20. In nonsmall cell lung cancer CNT1 565A showed a borderline significant positive influence on the early response for carriers of the variant allele which, however, did not translate to the survival of the patients PMID: 19107936
    21. 5-azacytidine as a novel substrate for hCNT1 and provides direct evidence that hCNT1 is involved in the DNA-demethylating effects of this drug PMID: 19139132
    22. The CNT1 promoter was characterized with respect to DNA response elements and their binding factors are reported. PMID: 19228884

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Concentrative nucleoside transporter (CNT) (TC 2.A.41) family
  • 組織特異性：
    Expressed in kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11001

    OMIM: 606207

    KEGG: hsa:9154

    STRING: 9606.ENSP00000286749

    UniGene: Hs.459187