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Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment.
基因功能參考文獻(xiàn):
There was a significant increase in protein levels of ZnT6 in the prefrontal cortex in Major depression disorder, relative to control subjects. PMID: 27661418
A genetic variant within SLC30A6 has a protective role in the severity of Rheumatoid Arthritis. PMID: 27758124
results of this study suggested that ZnT6 protein levels are decreased in the spinal cords of sporadic ALS patients. PMID: 25284286
The results of this study showed that signi fi cant positive correlations between ZIP1,ZnT1, and ZnT6 in most brain in patient with Alzheimer's disease. PMID: 22349685
our results suggest that alterations in Zn transport proteins ZnT-1, ZnT-4 and ZnT-6 may contribute to the pathology observed in preclinical Alzheimer's disease subjects before onset of clinical symptoms PMID: 19371353
Our results show that Zn transporter-4 and Zn transporter-6 are significantly (P<0.05) increased in hippocampus/parahippocampal gyrus of early Alzheimer's disease and Alzheimer's disease subjects. PMID: 16580781
hZnT-6 is up-regulated in response to cellular zinc depletion in Raji & THP-1 cells. PMID: 17971500
Data show that ZNT6 is extensively present in the Abeta-positive plaques in the cortex of human AD brains. PMID: 18639746
The cytosolic C-terminal tail of ZnT5 is important for its interaction with ZnT6 as a heterodimer. PMID: 19759014
Expressed in brain; especially in cerebellum, hippocampus, parahippocampal gyrus, superior and middle temporal gyrus. Also expressed in B-cells, colon, eye, and lung. Lower expression was present in bone, brain, cervix, ear, heart, kidney, muscle, nerve,