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SLC31A2 Antibody, HRP conjugated

  • 中文名稱：
    SLC31A2兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào)：
    CSB-PA021577LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SLC31A2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SLC31A2
  • 別名：
    SLC31A2; COPT2; CTR2; Probable low affinity copper uptake protein 2; Copper transporter 2; hCTR2; Solute carrier family 31 member 2
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Probable low affinity copper uptake protein 2 protein (44-93AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in low-affinity copper uptake.
  • 基因功能參考文獻(xiàn)：
    1. 11 single-nucleotide polymorphisms (SNPs) in CTR1, CTR2, ATP7A, and ATP7B were genotyped in these patients. PMID: 28737129
    2. Decreased expression of CTR2 is associated with clear cell renal cell carcinoma. PMID: 26411550
    3. Over-expression of CTR2 increased exchangeable Cu(+) by 150% and rendered the human epithelial 2008 cancer cell model 2.5-fold resistant to cisplatin. PMID: 24522273
    4. Increased CTR2 expression is associated with platinum resistance in epithelial ovarian cancer. PMID: 23564780
    5. hCTR2 is as an oligomeric membrane protein localized in lysosomes, which stimulates copper delivery to the cytosol of human cells at relatively high copper concentrations. PMID: 17617060
    6. Ctr2 promotes copper uptake at the plasma membrane and plays a role in regulating copper levels in COS-7 cells PMID: 17944601
    7. CTR2 functions by limiting drug accumulation, and its expression correlates with the sensitivity of human ovarian carcinoma cell lines to cisplatin. PMID: 19509135

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  • 亞細(xì)胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Copper transporter (Ctr) (TC 1.A.56) family, SLC31A subfamily
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11017

    OMIM: 603088

    KEGG: hsa:1318

    STRING: 9606.ENSP00000259392

    UniGene: Hs.24030