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SLC4A5 Antibody, FITC conjugated

  • 中文名稱：
    SLC4A5兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA874837LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SLC4A5 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SLC4A5
  • 別名：
    Electrogenic sodium bicarbonate cotransporter 4 antibody; MGC129662 antibody; NBC4 antibody; NBCe2 antibody; S4A5_HUMAN antibody; SLC4A5 antibody; Solute carrier family 4 member 5 antibody; Solute carrier family 4 sodium bicarbonate cotransporter member 5 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Electrogenic sodium bicarbonate cotransporter 4 protein (1071-1137AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH.
  • 基因功能參考文獻(xiàn)：
    1. NBCe2 activity is stimulated by an increase in intracellular sodium and is hyper-responsive in hRPTCs carrying HV SLC4A5 rs7571842 through an aberrant HNF4A-mediated mechanism PMID: 29642240
    2. NBCe2 could be important in proximal kidney tubule apical sodium and bicarbonate cotransport under high-salt conditions. PMID: 26447209
    3. we summarize the potential function of NBCe2 in the regulation of blood pressure, acid-base, and K(+) and Ca(2+) transport in the distal nephron--{REVIEW} PMID: 26136555
    4. Data indicate that 2 SNPs in SLC4A5 (rs7571842 and rs10177833) showed highly significant results and large effects sizes. PMID: 22987918
    5. The additive effect of rs10177833 of SLC4A5 on systolic blood pressure is statistically different between women with dark skin color and women with medium skin color (P = .0153). PMID: 22764636
    6. Summarizing, the observed associations with resting and submaximal-exercise cardiovascular and metabolic traits in the HERITAGE Family Study are likely due to neither variation in the promoter nor known coding SNPs of SLC4A5 PMID: 19384345
    7. Genomic organization of the DCTN1-SLC4A5 locus encoding both NBC4 and p150(Glued). PMID: 12063394
    8. These results additionally confirm the involvement of SLC4A5 with blood pressure control, although the mechanism is still unclear. PMID: 16365189

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  • 亞細(xì)胞定位：
    Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Anion exchanger (TC 2.A.31) family
  • 組織特異性：
    Highest expression observed in liver, spleen and testis; moderate expression in the choroid plexus, hippocampus, cerebrum and cerebellum of brain, and in kidney cortex and kidney medulla. Also observed in heart, pancreas, muscle, lung, placenta, stomach a
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18168

    OMIM: 606757

    KEGG: hsa:57835

    STRING: 9606.ENSP00000350475

    UniGene: Hs.594099