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SLCO1C1 Antibody, HRP conjugated

  • 中文名稱：
    SLCO1C1兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA868355LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：

    The product CSB-PA868355LB01HU is a polyclonal antibody produced in the rabbit with the recombinant human SLCO1C1 protein (297-348AA) immunized. It exists as an HRP-conjugated IgG. It is purified by protein G and reaches up to 95% in purity. It only reacts with human SLCO1C1 protein, a specific thyroid hormone transporter responsible for the sodium-independent uptake of thyroid hormones in brain tissues. The SLCO1C1 antibody has been validated for use only in ELISA analysis.

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SLCO1C1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SLCO1C1
  • 別名：
    OAT-RP-5 antibody; OATP-14 antibody; OATP-F antibody; OATP1 antibody; OATP1C1 antibody; OATPRP5 antibody; Organic anion transporter F antibody; Organic anion transporter polypeptide-related protein 5 antibody; organic anion transporting polypeptide 14 antibody; Organic anion-transporting polypeptide 14 antibody; SLC21A14 antibody; Slco1c1 antibody; SO1C1_HUMAN antibody; solute carrier family 21 (organic anion transporter), member 14 antibody; Solute carrier family 21 member 14 antibody; Solute carrier organic anion transporter family member 1C1 antibody; solute carrier organic anion transporter family, member 1C1 antibody; Thyroxine transporter antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Solute carrier organic anion transporter family member 1C1 protein (297-348AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a significant role in regulating T4 flux into and out of the brain.
  • 基因功能參考文獻：
    1. The genetic variant, rs3794271, located within the PDE3A-SLCO1C1 locus was analyzed for correlation with treatment response using both the EULAR classification criteria and absolute change in (Delta)DAS28 scores as outcome measures correlated with anti-TNF response in a large UK rheumatoid arthritis cohort. PMID: 27180831
    2. We found a highly significant association between PDE3A-SLCO1C1 and the clinical response to TNF blockers PMID: 25403996
    3. The PDE3A-SLCO1C1 locus rs3794271 SNP showed a highly significant association with anti-TNF treatment response. PMID: 23651021
    4. Compared with the adult cerebral cortex, mRNAs encoding OATP1A2, OATP1C1, OATP3A1 variant 2, OATP4A1, LAT2 and CD98 were reduced in fetal cortex at different gestational ages, whilst mRNAs encoding MCT8, MCT10, OATP3A1 variant 1 and LAT1 were similar. PMID: 21486766
    5. The strong expression of MCT10 and OATP1C1 in the human hypothalamus indicates a possible role in the regulation of the hypothalamus-pituitary-thyroid axis. PMID: 21508134
    6. We have isolated and functionally characterized OATP-F. OATP-F has a more selective substrate preference and may play an important role in the disposition of thyroid hormones in brain and testis. PMID: 12351693
    7. OATP1C1 polymorphisms are associated with fatigue and depression, but do not explain differences in neurocognitive functioning or appreciation of LT4-LT3 combination therapy. PMID: 18410547
    8. OATP1C1 mediates transport of thyroid hormones and increases the access of these substrates to the intracellular active sites of the deiodinases with no effect of genetic variation PMID: 18566113
    9. OATP14 mRNA and protein are strongly enriched in mouse and rat cerebral microvessels but not in human microvessels. PMID: 18687783
    10. Protein is highly expressed in the intestine, kidney, cholangiocytes and the blood-brain barrier. PMID: 19290786
    11. Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 18410547

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  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Organo anion transporter (TC 2.A.60) family
  • 組織特異性：
    Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum. Not strongly enriched in cerebral microvessels.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 13819

    OMIM: 613389

    KEGG: hsa:53919

    STRING: 9606.ENSP00000370964

    UniGene: Hs.47261