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SLU7 Antibody, HRP conjugated

  • 中文名稱：
    SLU7兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA021783LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SLU7 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    9G8 antibody; hSlu7 antibody; MGC9280 antibody; Pre mRNA splicing factor SLU7 antibody; Pre-mRNA-splicing factor slu7 antibody; SLU 7 antibody; slu7 antibody; SLU7 splicing factor homolog (S. cerevisiae) antibody; SLU7 splicing factor homolog antibody; SLU7_HUMAN antibody; splicing factor antibody; Step II splicing factor SLU7 antibody; Zinc knuckle motif containing antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Pre-mRNA-splicing factor SLU7 protein (138-310AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.
  • 基因功能參考文獻(xiàn)：
    1. these findings indicate that SLU7 is co-opted by hepatocellular carcinoma (HCC) cells and other tumor cell types to maintain survival, and identify this splicing regulator as a new determinant for the expression of the oncogenic miR-17-92 cluster. This novel mechanism may be exploited for the development of antitumoral strategies in cancers displaying such SLU7-miR-17-92 crosstalk PMID: 26804174
    2. SLU7 knockdown in liver cells resulted in profound changes in pre-mRNA splicing and gene expression, leading to impaired glucose and lipid metabolism, refractoriness to key metabolic hormones, and reversion to a fetal-like gene expression pattern. PMID: 24865429
    3. These observations together point to an altered recruitment and dependence on SLU7, suggesting its role in facilitating transitions that promote catalysis, and highlight the diversity in spliceosome assembly. PMID: 23754748
    4. RBM22 and hSlu7 differ significantly in their subcellular distributions under stress conditions, and RBM22 enhances the cytoplasmic translocation of hSlu7 under stress. PMID: 21122810
    5. The zinc-knuckle motif of hSlu7 determines the cellular localization of the protein through a nucleocytoplasmic-sensitive shuttling balance. PMID: 15181151
    6. hSlu7 has a broad effect on alternative splicing PMID: 15728250
    7. Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing PMID: 17804646

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  • 亞細(xì)胞定位：
    Nucleus. Nucleus speckle. Cytoplasm.
  • 蛋白家族：
    SLU7 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 16939

    OMIM: 605974

    KEGG: hsa:10569

    STRING: 9606.ENSP00000297151

    UniGene: Hs.435342