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SMC4 Antibody

  • 中文名稱(chēng)：
    SMC4兔多克隆抗體
  • 貨號(hào)：
    CSB-PA885725YA01HU
  • 規(guī)格：
    ￥440
  • 促銷(xiāo)：
    小規(guī)格抗體限時(shí)一口價(jià)
  • 圖片：
    • Immunohistochemistry analysis of human colon cancer using CSB-PA885725YA01HU at dilution of 1:100
    • Immunocytochemistry analysis of human kidney tissue using CSB-PA885725YA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA885725YA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) SMC4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SMC4
  • 別名：
    CAP C antibody; CAPC antibody; Chromosome associated polypeptide C antibody; Chromosome-associated polypeptide C antibody; hCAP C antibody; hCAP-C antibody; SMC 4 antibody; SMC protein 4 antibody; SMC-4 antibody; SMC4 antibody; SMC4_HUMAN antibody; SMC4L1 antibody; Structural maintenance of chromosomes 4 antibody; Structural maintenance of chromosomes 4 like 1 antibody; Structural maintenance of chromosomes protein 4 antibody; XCAP C homolog antibody; XCAP-C homolog antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Structural maintenance of chromosomes protein 4 protein (406-501AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，SMC4 Antibody (CSB-PA885725YA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于SMC4 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱(chēng) 應(yīng)用
    HRP CSB-PA885725YB01HU SMC4 Antibody, HRP conjugated ELISA
    FITC CSB-PA885725YC01HU SMC4 Antibody, FITC conjugated
    Biotin CSB-PA885725YD01HU SMC4 Antibody, Biotin conjugated ELISA
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
  • 基因功能參考文獻(xiàn)：
    1. analysis of functional differences of SMC2 and SMC4 hinge domain between condensins and cohesin in DNA recognition PMID: 26491021
    2. Results indicate that miR-124-5p may target the tumorigenesis gene, SMC4, which suggests that expression levels of miR-124-5p in plasma and FFPE samples. PMID: 25081869
    3. Knockdown of SMC-4 expression significantly suppressed the proliferation. PMID: 25422241
    4. SMC4 expression was significantly associated with tumor size, de-differentiation, advanced stages and vascular invasion of the primary liver cancers. PMID: 22842912
    5. mutation analysis of hCAP-C & hCAP-E in leukemia-lymphoma cell lines including 8 pyothorax-associated lymphoma (PAL); 3 of 8 PAL cell lines have hCAP-C or hCAP-E heterozygous mutations, indicating condensin mutations are relatively frequent in PAL PMID: 17488335

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  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
  • 蛋白家族：
    SMC family, SMC4 subfamily
  • 組織特異性：
    Widely expressed. Higher expression in testis, colon, thymus.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 14013

    OMIM: 605575

    KEGG: hsa:10051

    STRING: 9606.ENSP00000341382

    UniGene: Hs.58992