SNF1 Antibody
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中文名稱:SNF1兔多克隆抗體
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貨號:CSB-PA361945XA01SVG
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規(guī)格:¥440
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促銷:
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圖片:
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:SNF1
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別名:Carbon catabolite-derepressing protein kinase (EC 2.7.11.1) (Sucrose nonfermentating protein 1) SNF1 CAT1 CCR1 GLC2 PAS14 YDR477W D8035.20
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反應(yīng)種屬:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
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免疫原:Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SNF1 protein (435-633aa)
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免疫原種屬:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
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標(biāo)記方式:Non-conjugated
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:Protein G
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA, WB
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Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點詳情
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功能:Serine/threonine protein kinase essential for release from glucose repression. Catalytic subunit of the AMP-activated protein kinase complex also known as the SNF1 kinase complex (Snf1c), a central regulator of cellular energy homeostasis, which, in response to a fall in intracellular ATP levels, activates energy-producing pathways and inhibits energy-consuming processes. The complex phosphorylates histone H3 to form H3S10ph, which promotes H3K14ac formation, leading to transcriptional activation through TBP recruitment to the promoters. The complex also negatively regulates the HOG1 MAPK pathway in ER stress response including unfolded protein response (UPR). Under nutrient/energy depletion, the complex phosphorylates and activates PAS kinase PSK1 which in turn activates PBS1, leading to the inhibition of the TORC1 signaling pathway. SNF1 also interacts and phosphorylates adenylate cyclase CYR1 and negatively regulates the protein kinase A signaling pathway. Also phosphorylates and regulates the transcriptional activator CAT8.
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基因功能參考文獻:
- The deletion of Snf1 impairs the cell wall integrity by reducing the transcription of beta-glucan-related genes. PMID: 29733174
- The authors demonstrate that to permit long-term survival in response to sudden glucose depletion, yeast cells activate lipid-droplet (LD) consumption through micro-lipophagy (micro-lipophagy), in which fat is metabolized as an alternative energy source. AMP-activated protein kinase (AMPK) activation triggered this pathway, which required Atg14p. PMID: 28394250
- Here, the authors present evidence that Reg2 contributes to Snf1 Thr210 dephosphorylation. PMID: 27107116
- While SNF1 is essential for induction of gluconeogenesis, trehalose-6-phosphate/trehalose-6-phosphate synthesis is required for inactivation of gluconeogenesis in the presence of glucose, downstream and independent of SNF1 activity and the Cat8 and Sip4 transcription factors. PMID: 27189362
- Yeast have developed two distinct pathways for down-regulating Snf1 activity. The first is through direct dephosphorylation of the conserved activation loop threonine. The second is through phosphorylation of serine 214. PMID: 27524664
- The characteristics of SNF1 complex subunits, and the structure and regulation of the activity of the SNF1 complex has been presented. (Review) PMID: 27812987
- SNF1-dependent ADH2 promoter, or just the major transcription factor binding site, is sufficient to confer glucose-induced mRNA decay upon heterologous transcripts. PMID: 26667037
- these findings suggest that SNF1 (AMPK in mammalian systems) is the molecular target of RSV in S. cerevisiae. PMID: 26091703
- direct Arf activation by Snf1 regulates cellular responses to energy deprivation, in particular invasive cell growth PMID: 26198097
- the enhanced UBA-dependent longevity and oxidative stress response are at least partially dependent on the Fkh1 and Fkh2 stress response transcription factors, which in turn are shown to influence Snf1 gene expression. PMID: 25869125
- Snf1 Phosphorylates Adenylate Cyclase and Negatively Regulates Protein Kinase A-dependent Transcription in Saccharomyces cerevisiae PMID: 26309257
- Modulation of Snf1 phosphorylation and its protein level are important for adaptation to environmental stress. PMID: 25947383
- The Glc7-Reg1 complex takes part in the regulation of the AMP-activated serine/threonine protein kinase Snf1 in the regulation of the unfolded protein response. PMID: 25730376
- the AMPK Snf1p and ER stress kinase Ire1p regulated the HOG pathway. PMID: 25356552
- Xrn1 is required for Snf1-dependent mRNA homeostasis in response to nutrient availability. PMID: 25005228
- Data indicate that the Snf1-Mig1 signaling system monitors glucose concentration changes and absolute glucose levels to adjust the metabolism to a wide range of conditions. PMID: 24627493
- Epistasis analyses with mutants in cell wall integrity (CWI) signaling confirm that the SNF1 complex and the CWI pathway independently affect yeast cell integrity. PMID: 24486034
- Snf1 can be phosphorylated and activated in the presence of glucose without mediating glucose de-repression. PMID: 24529170
- the same kinases and phosphatase that regulate Snf1 also regulate Gpa1. PMID: 24003255
- Regulation of acetyl-CoA homeostasis represents another mechanism in the SNF1 regulatory repertoire. PMID: 24081331
- Findings indicate another way SNF1 function is regulated in response to carbon source. PMID: 24108357
- Snf1 is an AMPK family member that protects Saccharomyces cerevisiae cells upon glutathione oxidation PMID: 23472170
- Signalling pathways co-operate in the anticipatory Hxt5p activity in glucose-starved cells: as expected, the sucrose nonfermenting (Snf)1 AMP kinase pathway is a key element. PMID: 23495665
- Snf1 interacts with Por1 and Por2. PMID: 23104570
- we show that under derepressing conditions the recruitment of the histone acetyltransferase Gcn5 is abolished by SNF1 deletion, possibly explaining the lack of increased histone H3 acetylation and nucleosome remodelling. PMID: 22306658
- Snf1 is essential for glucose regulation of Hog1 MAPK and Sac1 traffic. PMID: 22882253
- The IL-1alpha-binding site was mapped to the HAT/Core module of the SAGA complex. PMID: 22879895
- Snf1 appears to affect multiple steps in gene regulation, including transcription factor binding, RNA polymerase II activity, and cytoplasmic mRNA stability. PMID: 22761425
- Data show that at the transcription level, Snf1 and inositol-choline interact directly through transcription factors. PMID: 22622761
- yeast Snf1 participates in metabolic checkpoint control that coordinates growth with nutrient availability. PMID: 22140226
- the role of Snf1 in tolerance to alkalinization is largely due to the function of the kinase in the adaptation of the cell to glucose scarcity, thus delineating with both the PKA and calcineurin pathways PMID: 22372618
- Snf1 has a role in upregulating the NADP(+)-dependent glutamate dehydrogenase under derepressing condition. direct interactions between Snf1 and TORC1 pathways are unlikely under nutrient-limited conditions. PMID: 22068328
- Subunit and domain requirements for adenylate-mediated protection of Snf1 kinase activation loop from dephosphorylation. PMID: 22065577
- Ubp8 can deubiquitinate Snf1, a highly conserved AMP-activated serine/threonine protein kinase that serves as an energy sensor in the cell. PMID: 21628526
- conformation of the SNF1 complex is crucial to maintenance of the inactive state during growth on high glucose and that the default state for SNF1 is one in which Thr(210) is phosphorylated and the kinase is active. PMID: 21561858
- The lack of Snf1 alpha-catalytic subunit down-regulates the growth rate and CLB5 expression, delaying Sld2 phosphorylation and G 1/S transition. PMID: 20505334
- C terminal of the Sak1 mediate interaction with Snf1 and activation of Snf1. PMID: 21216941
- The balance between the fermentative/oxidativein Saccharomyces cerevisiae is shifted by transcriptional deregulation of Snf1 via overexpression of the upstream activating kinase Sak1p. PMID: 21257817
- crystal structure of residues 41-440 of Snf1, which include the protein Ser/Thr kinase domain and auto-inhibitory domain, is reported at 2.4 A resolution PMID: 20823513
- This suggests that residues 450-500 may be constitutively associated with Snf4, and the remaining segments of the RS, as well as the AID, may be involved in regulating SNF1 activity. PMID: 20529674
- The expression of GPX1 is induced by glucose starvation and treatment with calcium chloride involving the Ras/cAMP pathway and Snf1. PMID: 20002498
- Data describe the role of the beta subunits in the regulation of Snf1 activity. PMID: 19897735
- Results suggest that Sak1 is involved in nitrogen signaling upstream of Snf1. PMID: 19880754
- Yeast Snf1 has a far more extensive function in controlling energy metabolism than reported earlier. PMID: 19888214
- Non-activated form of Snf1 regulates the Trk high-affinity potassium transporter, encoded by the TRK1 and TRK2 genes. PMID: 15642368
- hyperactivation of Snf1 kinase, as caused by reg1Delta, suppresses the Spt(-) phenotype of spt21Delta PMID: 15744051
- Gln3 phosphorylation levels are regulated as follows: (i) depends on Snf1 kinase as observed during carbon starvation, (ii) is Snf1-independent as observed during both carbon starvation and MSX treatment, and (iii) is rapamycin-induced dephosphorylation PMID: 15911613
- crystal structure at 2.2A resolution of the protein kinase domain (KD) of the catalytic subunit of yeast AMPK (commonly known as SNF1) PMID: 16236260
- Snf1p-dependent Spt-Ada-Gcn5-acetyltransferase (SAGA) recruitment and chromatin remodeling activities on the HXT2 and HXT4 promoters. PMID: 16368692
- analysis of Snf1-dependent and Snf1-independent pathways of constitutive ADH2 expression in Saccharomyces cerevisiae PMID: 16415371
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亞細(xì)胞定位:Cytoplasm. Nucleus. Nucleus membrane; Peripheral membrane protein.
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蛋白家族:Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
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數(shù)據(jù)庫鏈接:
KEGG: sce:YDR477W
STRING: 4932.YDR477W
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