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  4. SNRK Antibody, Biotin conjugated

SNRK Antibody, Biotin conjugated

  • 中文名稱：
    SNRK兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA868301ND01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SNRK Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SNRK
  • 別名：
    DKFZp779A1866 antibody; FLJ20224 antibody; HSNFRK antibody; KIAA0096 antibody; SNF related kinase antibody; SNF related serine/threonine protein kinase antibody; SNF-related serine/threonine-protein kinase antibody; SNF1 related kinase antibody; SNF1-related kinase antibody; SNFRK antibody; Snrk antibody; SNRK_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Peptide sequence from Human SNF-related serine/threonine-protein kinase protein (340-360AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.
  • 基因功能參考文獻(xiàn)：
    1. Study shows that TRIB3 binds to SNRK, and downregulates UCP3 through PPARalpha. SNRK is increased in cardiomyopathy patients, and SNRK reduces infarct size after ischaemia/reperfusion. SNRK also decreases cardiac cell death in a UCP3-dependent manner. PMID: 28117339
    2. Report the crystal structure of an N-terminal SNRK fragment containing kinase and adjacent ubiquitin-associated (UBA) domains. This structure shows that the UBA domain binds between the N- and C-lobes of the kinase domain. The mode of UBA binding in SNRK largely resembles that in AMPK and brain specific kinase (BRSK), however, unique interactions play vital roles in stabilizing the KD-UBA interface of SNRK. PMID: 29061304
    3. SNRK in cardiomyocytes is responsible for maintaining cardiac metabolic homeostasis, which is mediated in part by ROCK, and alteration of this homeostasis influences cardiac function in the adult heart. PMID: 27780848
    4. Differential expression of SNRK in early versus late stage disease suggests specific roles for SNRK in ovarian cancer metastasis. PMID: 28722495
    5. SNRK inhibits colon cancer cell proliferation through calcyclin-binding protein up-regulation and beta-catenin degradation, which results in reduced proliferation signaling. PMID: 22874833
    6. These findings reveal a novel function for SNRK in the regulation of colon cancer cell proliferation and beta-catenin signaling. PMID: 22874833
    7. SNRK could mediate some of the physiological effects of LKB1 PMID: 15733851

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family
  • 組織特異性：
    Expressed in hematopoietic progenitor cells and leukemic cell lines. Weakly expressed in the testis.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 30598

    OMIM: 612760

    KEGG: hsa:54861

    STRING: 9606.ENSP00000296088

    UniGene: Hs.476052