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SNRPD1 Antibody, FITC conjugated

  • 中文名稱：
    SNRPD1兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA022332LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SNRPD1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SNRPD1
  • 別名：
    AA407109 antibody; AL023031 antibody; HsT2456 antibody; Sm D1 antibody; Sm-D autoantigen antibody; Sm-D1 antibody; Small nuclear ribonucleoprotein D1 polypeptide antibody; Small nuclear ribonucleoprotein Sm D1 antibody; SmD autoantigen antibody; SMD1 antibody; SMD1_HUMAN antibody; snRNP core protein D1 antibody; SNRPD antibody; Snrpd1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Small nuclear ribonucleoprotein Sm D1 protein (1-119AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.
  • 基因功能參考文獻：
    1. Data show that the elevation of cerebrospinal fluid anti-Sm antibodies through transudation from systemic circulation due to damaged blood-brain barrier (BBB) plays a critical role in the pathogenesis of acute confusional state (ACS). PMID: 25273532
    2. The interaction of SMN with the spliceosomal SmD1 (also known as SNRPD1), severely decreases SMN-coilin interaction and prevents Cajal body assembly. PMID: 24413165
    3. Overexpression of SNRPD1 is associated with highly aggressive breast cancers. PMID: 23358685
  • 亞細胞定位：
    Cytoplasm, cytosol. Nucleus.
  • 蛋白家族：
    SnRNP core protein family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11158

    OMIM: 601063

    KEGG: hsa:6632

    STRING: 9606.ENSP00000300413

    UniGene: Hs.464734