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SPY Antibody

  • 中文名稱：
    SPY兔多克隆抗體
  • 貨號(hào)：
    CSB-PA300608XA01ENV
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時(shí)一口價(jià)
  • 圖片：
    • Western Blot
      Positive WB detected in Recombinant protein
      All lanes: SPY antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 26.8 kDa
      Observed band size: 33 kDa
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    SPY
  • 別名：
    Periplasmic chaperone Spy (Spheroplast protein Y) spy b1743 JW1732
  • 反應(yīng)種屬：
    Escherichia coli (strain K12)
  • 免疫原：
    Recombinant Escherichia coli (strain K12) SPY protein (52-147aa)
  • 免疫原種屬：
    Escherichia coli (strain K12)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Protein G
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    An ATP-independent periplasmic chaperone, decreases protein aggregation and helps protein refolding. Binds substrate over a large region of its convex inner surface. Substrate protein folds while it is bound to chaperone. Increasing Spy flexibility increases its substrate affinity and overall chaperone activity (shown for 3 different substrates). Protects proteins in vitro against tannin inactivation; tannins have antimicrobial activity. Overexpression enhances the stability of otherwise unstable periplasmic proteins.
  • 基因功能參考文獻(xiàn)：
    1. Visualizing of Spy chaperone-assisted Im7 protein folding has been reported. PMID: 27239796
    2. Experimental results on Spy-Im7 interactions were used to construct a model for how this chaperone interacts with its clients. It appears that Spy binds to and releases client proteins in a regulated fashion that uses client protein folding as its own cue for release. PMID: 27293188
    3. Spy rapidly associates with its substrate, immunity protein 7 (Im7), thereby eliminating Im7's potential for aggregation. PMID: 26619265
    4. Establish a good relationship between the degree of instability and the improvement chaperone activity of spy variants. PMID: 24497545
    5. Report of the crystal structure of Escherichia coli spheroplast protein y (EcSpy). PMID: 20799348
    6. The induction of spy gene transcription by external zinc may include multiple steps such as through sensing the zinc-induced envelope disorder by BaeSR. PMID: 17884222

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  • 亞細(xì)胞定位：
    Periplasm.
  • 蛋白家族：
    CpxP/Spy family
  • 數(shù)據(jù)庫(kù)鏈接：