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ST5 Antibody

  • 中文名稱：
    ST5兔多克隆抗體
  • 貨號：
    CSB-PA022758GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ST5
  • 別名：
    DENND2B antibody; DENN domain containing protein 2B antibody; DENN domain-containing protein 2B antibody; DENN/MADD domain containing 2B antibody; HeLa tumor suppression 1 antibody; HTS1 antibody; p126 antibody; ST 5 antibody; ST5 antibody; ST5_HUMAN antibody; Suppression of tumorigenicity 5 antibody; Suppression of tumorigenicity 5 protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human ST5
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產品評價

靶點詳情

  • 功能：
    May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane.; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.; May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable).
  • 基因功能參考文獻：
    1. Here, we discover that intersectin-s binds DENND2B, a guanine nucleotide exchange factor for the exocytic GTPase Rab13, and this interaction promotes recycling of ligand-free EGFR to the cell surface. Our study thus reveals a novel mechanism controlling the fate of internalized EGFR with important implications for cancer. PMID: 29030480
    2. DENND2B interacts with the Rab13 effector MICAL-L2 at the cell periphery, and this interaction is required for the dynamic remodeling of the cell's leading edge. PMID: 25713415
    3. Using RNA in situ hybridisation in mouse, the authors found that St5 is expressed in the frontal cortex during embryonic development. In adult mouse brain, expression of St5 was especially high in the hippocampal area and cerebellum. PMID: 19843505
  • 亞細胞定位：
    [Isoform 1]: Cytoplasm, cell cortex. Cell membrane. Recycling endosome.
  • 組織特異性：
    Widely expressed with the exception of peripheral blood lymphocytes. Isoform 1 is expressed in several epithelial and fibroblast (including tumorigenic) but absent in lymphoid cell lines (at protein level). Isoform 3 is expressed in primary cell or weakly
  • 數據庫鏈接：

    HGNC: 11350

    OMIM: 140750

    KEGG: hsa:6764

    STRING: 9606.ENSP00000319678

    UniGene: Hs.117715