STAG3 Antibody, FITC conjugated
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中文名稱:STAG3兔多克隆抗體, FITC偶聯(lián)
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貨號:CSB-PA022787LC01HU
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規(guī)格:¥880
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱:Rabbit anti-Homo sapiens (Human) STAG3 Polyclonal antibody
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Uniprot No.:
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基因名:STAG3
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別名:STAG3 antibody; Cohesin subunit SA-3 antibody; SCC3 homolog 3 antibody; Stromal antigen 3 antibody; Stromalin-3 antibody
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宿主:Rabbit
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反應(yīng)種屬:Human
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免疫原:Recombinant Human Cohesin subunit SA-3 protein (1056-1212AA)
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:FITC
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:>95%, Protein G purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式:Liquid
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I.
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基因功能參考文獻(xiàn):
- c.677C > G associated with primary ovarian insufficiency PMID: 28802712
- Loss of STAG2 or STAG3, which encode subunits of the cohesin complex, in melanoma cells results in resistance to BRAF inhibitors (BRAFi). Loss-of-function mutations in STAG2, as well as decreased expression of STAG2 or STAG3 proteins were found in several tumor samples from patients with acquired resistance to BRAFi and in BRAFi-resistant melanoma cell lines. PMID: 27500726
- STAG3 truncating variant as the cause of primary ovarian insufficiency has been found in two sisters in a consanguineous Lebanese family. PMID: 26059840
- We identified a homozygous 1-bp deletion inducing a frameshift mutation in STAG3 on chromosome 7. Female mice devoid of Stag3 are sterile. PMID: 24597867
- we show evidence for the involvement of a common allele of STAG3 in the development of epithelial ovarian cancer PMID: 20635389
- identified as one of five genes containing 11 somatic mutations in a panel that included 132 colorectal cancers, then demonstrated that down-regulation of such homologs resulted in chromosomal instability and chromatid cohesion defects in human cells PMID: 18299561
- plays a role in regulation of transcription due to genetic imprinting, sister chromatid exchange, chromosome segregation and as an insulator element. (review) PMID: 18788457
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相關(guān)疾病:Premature ovarian failure 8 (POF8)
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亞細(xì)胞定位:Nucleus. Chromosome. Chromosome, centromere.
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蛋白家族:SCC3 family
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組織特異性:Testis specific.
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數(shù)據(jù)庫鏈接:
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