STK10 Antibody
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中文名稱(chēng):STK10兔多克隆抗體
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貨號(hào):CSB-PA003160
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規(guī)格:¥880
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圖片:
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:STK10
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別名:LOK antibody; Lymphocyte oriented kinase antibody; Lymphocyte-oriented kinase antibody; PRO2729 antibody; Serine threonine protein kinase 10 antibody; Serine/threonine-protein kinase 10 antibody; STK10 antibody; STK10_HUMAN antibody
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宿主:Rabbit
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反應(yīng)種屬:Human
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免疫原:Synthesized peptide derived from the Internal region of Human LOK.
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
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抗體亞型:IgG
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純化方式:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:WB, ELISA
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推薦稀釋比:
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:20000 -
Protocols:
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儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.
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基因功能參考文獻(xiàn):
- Binding of phosphatidylinositol 4,5-biphosphate to ezrin induces a conformational change permitting the insertion of the LOK C-terminal domain to wedge apart the membrane and F-actin-binding domains of ezrin. The N-terminal LOK kinase domain can then access a site 40 residues distal from the consensus sequence that collectively direct phosphorylation of the appropriate threonine residue. PMID: 28430576
- The gene signature of OPA1, CTSA, NDUFA1, STK10 and PRDX1 was able to identify patients post-implant with a sensitivity of 91% and a specificity of 86% in discrimination between post-implant group and healthy controls. PMID: 27177495
- STK10 functions as a tumor suppressor gene, and dysfunction of STK10 activity either through polymorphism or somatic mutations may confer anti-apoptotic effects contributing to carcinogenesis. PMID: 23842845
- It was shown that lymphocyte-oriented and STE20 kinase were sufficient to restrict ezrin function to the apical domain. Both kinases were enriched in microvilli and locally activated there. PMID: 23209304
- genetic polymorphism is associated with aspirin-intolerant asthma in a Korean population PMID: 21905501
- Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells PMID: 11903060
- Stk10 is a novel polo-like kinase kinase that cooperates with hSlk to regulate Plk1 function in human cells PMID: 12639966
- These studies identify a new ERM kinase of importance in lymphocytes and confirm the role of ezrin-radixin-moesin phosphorylation in regulating cell shape and motility. PMID: 19255442
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相關(guān)疾?。?/div>Testicular germ cell tumor (TGCT)亞細(xì)胞定位:Cell membrane; Peripheral membrane protein.蛋白家族:Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily組織特異性:Highly expressed in rapidly proliferating tissues (spleen, placenta, and peripheral blood leukocytes). Also expressed in brain, heart, skeletal muscle, colon, thymus, kidney, liver, small intestine and lung.數(shù)據(jù)庫(kù)鏈接:
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