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STRADA Antibody

  • 中文名稱：
    STRADA兔多克隆抗體
  • 貨號：
    CSB-PA745759ESR2HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時一口價
  • 圖片：
    • Western blot
      All lanes: STRADA antibody IgG at 1.98μg/ml + Rat heart tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 49, 39, 44, 34, 42, 35 kDa
      Observed band size: 49 kDa
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA745759ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA745759ESR2HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) STRADA Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    STRADA antibody; LYK5 antibody; STRAD antibody; STE20-related kinase adapter protein alpha antibody; STRAD alpha antibody; STE20-related adapter protein antibody; Serologically defined breast cancer antigen NY-BR-96 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Rat
  • 免疫原：
    Recombinant Human STE20-related kinase adapter protein alpha protein (25-210AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產品評價

靶點詳情

  • 功能：
    Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.
  • 基因功能參考文獻：
    1. We identified for the first time a homozygous point mutation in STRADA causing PMSE. Additional bi-allelic mutations related to PMSE thus far have not been observed in Baylor approximately 6,000 consecutive clinical WES cases, supporting the rarity of this disorder. PMID: 27170158
    2. aberrant nuclear accumulation of LKB1 caused by STRADalpha deficiency contributes to hyperactivation of mTORC1 signaling and disruption of neuronal lamination during corticogenesis PMID: 20424326
    3. Several novel splice isoforms of STRADalpha that differentially affect the kinase activity, complex assembly, subcellular localization of LKB1 and the activation of the LKB1-dependent AMPK pathway were discovered. PMID: 17921699
    4. study describes structure of the core heterotrimeric LKB1-STRADalpha-MO25alpha complex, revealing an unusual allosteric mechanism of LKB1 activation; structure also reveals how mutations in Peutz-Jeghers syndrome & sporadic cancers impair LKB1 function PMID: 19892943
    5. Identification and characterization of an LKB1-specific adaptor protein and substrate, STRAD. Results imply that STRAD plays a key role in regulating the tumor suppressor activities of LKB1. PMID: 12805220
    6. identify a multifactored mechanism to control LKB1 localization, and they suggest that the STRADbeta-LKB1 complex might possess unique functions in the nucleus PMID: 18256292
    7. LKB1 deacetylation is regulated by SIRT1 and that this in turn influences its intracellular localization, association with STRAD, kinase activity, and ability to activate AMPK. PMID: 18687677
    8. ATP and MO25alpha cooperate to maintain STRADalpha in an "active" closed conformation required for LKB1 activation. PMID: 19513107

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  • 相關疾?。?/div>
    A homozygous 7-kb deletion involving STRADA is a cause of a syndrome characterized by polyhydramnios, megalencephaly and symptomatic epilepsy.
  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30172

    OMIM: 608626

    KEGG: hsa:92335

    STRING: 9606.ENSP00000336655

    UniGene: Hs.514402