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SYNE4 Antibody, HRP conjugated

  • 中文名稱：
    SYNE4兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA847615LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SYNE4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SYNE4
  • 別名：
    SYNE4 antibody; C19orf46 antibody; Nesprin-4 antibody; KASH domain-containing protein 4 antibody; KASH4 antibody; Nuclear envelope spectrin repeat protein 4 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Nesprin-4 protein (1-242AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus.
  • 基因功能參考文獻：
    1. progressive high-frequency hearing loss in 2 families of Iraqi Jewish ancestry was due to homozygosity for mutation SYNE4 c.228delAT. SYNE4, a gene not previously associated with hearing loss, encodes nesprin-4, a protein expressed in outer hair cells. PMID: 23348741
  • 相關(guān)疾?。?/div>
    Deafness, autosomal recessive, 76 (DFNB76)
  • 亞細胞定位：
    Nucleus outer membrane; Single-pass type IV membrane protein.
  • 蛋白家族：
    Nesprin family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 26703

    OMIM: 615535

    KEGG: hsa:163183

    STRING: 9606.ENSP00000316130

    UniGene: Hs.436743