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TBCB Antibody, FITC conjugated

  • 中文名稱：
    TBCB兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA03169C0Rb
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TBCB Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TBCB
  • 別名：
    CG22 antibody; CKAPI antibody; Cytoskeleton associated protein 1 antibody; Cytoskeleton associated protein CKAPI antibody; Cytoskeleton-associated protein 1 antibody; Cytoskeleton-associated protein CKAPI antibody; Tbcb antibody; TBCB_HUMAN antibody; Tubulin folding cofactor B antibody; Tubulin specific chaperone B antibody; Tubulin-folding cofactor B antibody; Tubulin-specific chaperone B antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Tubulin-folding cofactor B protein (1-244AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth.
  • 基因功能參考文獻：
    1. Data indicate a microRNA-1825/TBCB/TUBA4A pathway as a putative pathogenic cascade in both familial ALS (fALS) and both sporadic (sALS). PMID: 30030593
    2. the role of the human TBCE and TBCB chaperones in alpha-tubulin-beta-tubulin dissociation, was investigated. PMID: 25908846
    3. results support a role for MAP1 proteins in promoting efficient retrograde trafficking of HIV-1 by stimulating the formation of stable microtubules and mediating the association of HIV-1 cores with microtubules. PMID: 25505242
    4. Overexpression of TBCB leads to the decreased localization of p150 to the microtubule network that might result in a functional modulation of this protein complex. PMID: 22777741
    5. TBCB localizes at spindle and midzone microtubules during mitosis. PMID: 22940919
    6. These findings identified TCoB as the third cytoskeleton protein to be nitrated and suggest a previously undescribed mechanism, whereby growth factor signaling may coordinately integrate nitric oxide signaling in the regulation of microtubule dynamics. PMID: 18048340
    7. TBCB functions as a microtubule density regulator in microglia during activation, and provide an insight into understanding of mechanisms controlling microtubule reorganization during microglial transition between phenotypes. PMID: 19038251
    8. Study demonstrates that, unlike its counterpart TBCE, TBCB only moderately destabilizes microtubules; neither TBCB abundance nor microtubule organization or densities are altered in giant axonal neuropathy mutant fibroblasts. PMID: 19168853

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  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    TBCB family
  • 組織特異性：
    Found in most tissues.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1989

    OMIM: 601303

    KEGG: hsa:1155

    STRING: 9606.ENSP00000221855

    UniGene: Hs.31053