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  4. TERF2 Antibody, FITC conjugated

TERF2 Antibody, FITC conjugated

  • 中文名稱：
    TERF2兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA620883LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TERF2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Telomeric DNA binding protein antibody; Telomeric DNA-binding protein antibody; Telomeric repeat binding factor 2 antibody; Telomeric repeat binding protein 2 antibody; Telomeric repeat-binding factor 2 antibody; TERF 2 antibody; Terf2 antibody; TERF2_HUMAN antibody; TRBF 2 antibody; TRBF2 antibody; TRF 2 antibody; TRF2 antibody; TTAGGG repeat binding factor 2 antibody; TTAGGG repeat-binding factor 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Telomeric repeat-binding factor 2 protein (78-238AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.
  • 基因功能參考文獻：
    1. ROC curves analysis displayed TERF2 and RTA as two promising markers in disease diagnosis. In addition to that, Univariate analysis of clinico-pathological parameters and studied genes, TERF2 and RTA demonstrated significant association of these molecules in disease progression and are good predictor of disease course thus suggesting their utility in prognosis of MM. PMID: 29043869
    2. Both GEM and CAP caused telomere shortening and increased expression of TRF2 with improved ascites in nude mice and decreased in vitro clonogenic activity. TRF2 knockdown altered telomeres to a shortened but new status that may evade XPF-dependent telomere loss and conferred resistance of SKOV3.ip1 ascites cells to low-dose GEM and CAP. PMID: 28088627
    3. We demonstrate that promoter binding by TRF2 mediates PCGF3 promoter activity, and both the N-terminal and C-terminal domains of TRF2 are necessary for promoter activity PMID: 29589913
    4. The reports the crystal structure of the N-terminal domain of TIN2 in complex with TIN2-binding motifs from TPP1 and TRF2, revealing how TIN2 interacts cooperatively with TPP1 and TRF2. PMID: 29160297
    5. the excessive HULC plus MALAT1 reduced the methylation of the TERC promoter dependent on TRF2, increasing the TERC expression that causes the increase of interplay between TRET and TERC. PMID: 27782152
    6. TERF2 knockdown by RNA interference had no effect on cell proliferation, migration, senescence and apoptosis. Instead, TERF2 knockdown increased the expression of cytokines implicated in inflammation and angiogenesis, except for vascular endothelial growth factor. PMID: 27329590
    7. the telomere stability is under direct control of one of the major pro-oncogenic signaling pathways (RAS/RAF/MEK/ERK) via TRF2 phosphorylation. PMID: 27366950
    8. the B-domain improves TRF2's interaction with DNA via enhanced long-range electrostatic interactions. PMID: 28981702
    9. our findings describe TRF2 as a novel SIRT6 substrate and demonstrate that acetylation of TRF2 plays a crucial role in the regulation of TRF2 protein stability, thus providing a new route for modulating its expression level during oncogenesis and damage response. PMID: 27923994
    10. The results suggest that dimerized TRF2 recruits origin recognition complex and stimulates pre-replication complex formation at telomeres through the TRFH domain. PMID: 27836746
    11. Studied the disruption pattern of of 3D telomere-TRF2 interaction in the progression from mononuclear Hodgkin cells (H) to multinucleated Reed-Sternberg cells (RS). PMID: 28436953
    12. TRF2, a component of shelterin, binds to core histones to protect chromosome ends from inappropriate DNA damage response and loss of telomeric DNA. The N-terminal Gly/Arg-rich domain (GAR domain) of TRF2 directly binds to the globular domain of core histones. PMID: 27514743
    13. TRF2 deficiency led to a 1,5-2 fold increase in the radiosensitivity of hMSC-telo1 cells through telomere destabilization. PMID: 26598048
    14. DREEM imaging shows that in contrast to chromatin with DNA wrapping around histones, large TRF2-DNA complexes (with volumes larger than TRF2 tetramers) compact DNA inside TRF2 with portions of folded DNA appearing at the edge of these complexes. PMID: 26856421
    15. observed that the expression of Sp1 is down-regulated in the TRF2(DeltaBDeltaM)-induced senescence, which was mediated by ATM and p38 MAPK PMID: 26906205
    16. Data show that isoform beta2 of the heregulin (HRGbeta2) localizes at telomeres with the telomere-associated proteins TRF2 and RAP1. PMID: 26318724
    17. These observations suggest that TRF2 is a good candidate for the attachment of telomeres to the nuclear envelope in somatic cells PMID: 26572976
    18. Through a combination of biochemical, biophysical and structural approaches, we unveiled a unique mode of assembly between RAP1 and TRF2 PMID: 26748096
    19. that a dimer of the shelterin subunit TRF2 wraps approximately 90 bp of DNA through several lysine and arginine residues localized around its homodimerization domain. PMID: 26774283
    20. TRF2 overexpression results in replication stalling in duplex telomeric repeat tracts and formation of telomeric ultrafine anaphase bridges, ultimately leading to stochastic loss of telomeric sequences. PMID: 26640040
    21. APB formation induced clustering of telomere repeats, telomere compaction and concomitant depletion of the shelterin protein TRF2 (also known as TERF2). PMID: 25908860
    22. Study demonstrates that TRF2 interacts with and is sumoylated by PIAS1 and RNF4 targets SUMO-conjugated TRF2 for ubiquitination, thereby decreasing its stability suggesting that TRF2 status provides a molecular switch that controls its level at telomeres. PMID: 26450775
    23. TRF2 is a specific target of miR-23a, and uncover a previously unknown role for miR-23a in telomere regulation and cellular senescence PMID: 25753893
    24. The variability of genes encoding for TERF1 and TNKS2 is important for keeping the integrity of the telomere structure and show a significant association with longevity. PMID: 25631672
    25. represses TERRA transcription through its homodimerization domain PMID: 25359189
    26. interaction between with lamin A/C on chromosome structure and cellular and organismal aging PMID: 25399868
    27. data suggest that TRF2 is a radioresistant protein in A549 and U2OS cells. PMID: 25609072
    28. TRF2-mediated counterbalance between hREST4 and REST is vital for both the generation and maintenance of neural progenitor cells PMID: 24740933
    29. TRF2 binds and transactivates the promoter of the angiogenic tyrosine kinase platelet-derived growth factor receptor beta (PDGFRbeta). PMID: 25437559
    30. Data show that full-length repressor activator protein 1 (Rap1) binds to full-length telomeric repeat binding factor 2 (TRF2) with high affinity and equimolar ratio. PMID: 25675958
    31. TRF2 is involved in the recruitment of RTEL1 to facilitate t-loop disassembly at telomeres in S phase. PMID: 25620558
    32. these results suggest that the altered nuclear staining of methylated TRF2 may represent nuclear structural alteration associated with cellular senescence. PMID: 24721747
    33. KIP binding to TRF2 enhances the telomere-binding activity of TRF2, suggesting that KIP acts as a positive regulator of TRF2 function. PMID: 25012820
    34. Findings lead authors to propose a model in which telomeres are directly protected from c-NHEJ via TRF2 impeding Ku's ability to synapse telomere ends. PMID: 24095731
    35. Aging in hESC-derived CMs correlated with reduced membrane potential in mitochondria, the accumulation of lipofuscin, a slower beating pattern, and the downregulation of human telomerase RNA (hTR) and cell cycle regulating genes. PMID: 22843416
    36. The wnt/beta-catenin signalling pathway maintains a level of TRF2 critical for telomere protection. PMID: 23429341
    37. High level of TRF2 in tumour cells decreased their ability to recruit and activate natural killer cells and contribute to oncogenesis. PMID: 23792691
    38. The TRF2, is recruited to sites of DNA damage and plays critical roles in the DNA damage response. PMID: 22841872
    39. Doxorubicin induces uPAR-mediated proteasomal activity & ubiquitination of TRF2 in VSMC from umbilical artery. uPAR also controls nuclear accumulation and DNA binding of TRF2. PMID: 23172421
    40. Low TRF2 expression is associated with chronic lymphocytic leukemia. PMID: 22878603
    41. results indicate that REST-dependent TRF2 expression renders cancer cells resistant to DNA damage during oxidative stress PMID: 22821339
    42. as hTRF2 recruits hRap1 to telomeric sequences, hRap1 alters the affinity of hTRF2 and its binding preference on telomeric DNA. Moreover, the TRF2-Rap1 complex has higher ability to re-model telomeric DNA PMID: 23086976
    43. Gemcitabine causes telomere shortening by stabilizing TRF2 that is required for XPF-dependent telomere loss. Overexpression of TRF2 in the absence of gemcitabine also causes telomere shortening with simultaneous association of TRF2 with XPF/ERCC1. PMID: 22704123
    44. The TRF2 stimulates the binding and enzymatic activities of the LP-BER proteins APE1, FEN1 and LigI both individually and when they act together in reconstituted LP-BER using a telomeric substrate. PMID: 22336916
    45. The telomeric protein TRF2 binds Telomeric repeat-containing RNA (TERRA) via interactions that necessitate the formation of a G-quadruplex structure rather than the TERRA sequence per se. PMID: 22780456
    46. TRF2 negatively regulates the number of nucleosomes at human telomeres by a cell cycle-dependent mechanism that alters internucleosomal distance. PMID: 22536324
    47. increased TRF2 immunostaining intensity in invasive carcinomas is associated with shorter telomeres and shorter telomeres correlate with a higher TNM stage PMID: 20625812
    48. Data show that mutant template human telomerase RNAs (MT-hTers) induce DNA damage after phosphorylation of ATM and p53 via suppression of TRF2, which may eventually lead to apoptosis via elevation of GADD45gamma. PMID: 21824286
    49. Study investigated the binding sites of telomeric proteins along human chromosomes; RAP1 and TRF2 could be found on a small number of interstitial sites, including regions that are proximal to genes. PMID: 21423278
    50. Silencing TRF2 can inhibit proliferation of Hep-2 cells. PMID: 21395184

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  • 亞細胞定位：
    Nucleus. Chromosome, telomere. Note=Colocalizes with telomeric DNA in interphase cells and is located at chromosome ends during metaphase.
  • 組織特異性：
    Ubiquitous. Highly expressed in spleen, thymus, prostate, uterus, testis, small intestine, colon and peripheral blood leukocytes.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11729

    OMIM: 602027

    KEGG: hsa:7014

    STRING: 9606.ENSP00000254942

    UniGene: Hs.63335