TET2 Antibody

1. Tet2/Nras double-mutant leukemia showed preferential sensitivity to MAPK kinase (MEK) inhibition in both mouse model and patient samples PMID: 29275866
2. TET2-mutated myeloid malignancy patients have significantly more mutational events than patients with wild-type TET2, suggesting a novel TET2 loss-mediated mechanism of hematological malignancy pathogenesis. PMID: 28440315
3. Authors have demonstrated that excessive amounts of STAT5 may bind more TET2 to the FOXP3-TSDR and upregulate FOXP3 expression via DNA demethylation. Study improved the mechanism of FOXP3-TSDR hypomethylation in tumor-infiltrating CD4(+) T cells of CRC patients. PMID: 30013992
4. the dysregulation of TET2/E-cadherin/beta-catenin regulatory loop is a critical oncogenic event in HCC progression PMID: 29331390
5. The expression of TET1, TET2, and TET3 was lower in the villi in early pregnancy loss group than in normal pregnancy group PMID: 30074219
6. this is the first evidence to suggest that TET2 mutations promote clonal dominance with aging by conferring TNFalpha resistance to sensitive bone marrow progenitors while also propagating such an inflammatory environment. PMID: 29195897
7. Our data demonstrate that TET2 SNP rs2454206AG/GG correlates with improved overall survival and event-free survival in childhood acute myeloid leukemia featuring intermediate-risk cytogenetics. No difference in TET2 expression levels in acute myeloid leukemia with TET2 SNP rs2454206(AA) and TET2 SNP rs2454206(AG/GG) was detected, indicating that TET2 SNP rs2454206 status does not affect TET2 expression in pediatric AML. PMID: 29664232
8. TET2 plays an important role in the pathogenesis of diabetic nephropathy by activating TGFbeta1 expression through demethylation of CpG islands in the TGFbeta1 regulatory region PMID: 29705354
9. Studies indicate that TET methylcytosine dioxygenase 2 (TET2) plays an important role in preventing atherosclerosis by repressing vascular smooth muscle cell (VSMC) phenotype transformation, protecting endothelial cells (ECs) from damage and dysfunction, and inhibiting inflammation [Review]. PMID: 29653065
10. The results of the present study demonstrated that the genes cryptochrome circadian clock 1, zinc finger protein (ZNF) interacting with K protein 1, ZNF134, ZNF256 and ZNF615, which were hypermethylated and downregulated in Diffuse large B-cell lymphoma (DLBCL) patients with TET2 mutations, were the key genes in the association between DLBCL and TET mutations. PMID: 28731140
11. Data suggest that deregulated expression of TET2 by DNA hypermethylation may contribute to the aberrantly low level of 5hmC in parathyroid carcinoma and further that TET2 plays a cell growth and cell migratory regulatory role and may constitute a parathyroid tumor suppressor gene. PMID: 28642344
12. This result suggests that TET2(P1962T) mutation in association with germline RUNX1(R174Q) mutation leads to amplification of a haematopoietic clone susceptible to acquire other transforming alterations PMID: 27997762
13. DNMT3A senses the TGF-beta signal and silences TET2 and TET3 promoters to induce the epithelial-mesenchymal transition-like process and metastasis in melanoma. PMID: 27852070
14. TET2 functions as a resistance factor against DNA methylation in gastric epithelial cells and repression of TET2 contributes to DNA methylation acquisition during Epstein Barr virus infection. PMID: 27829228
15. Patients with mutations 6 showed higher rate of achieving major molecular response than those<6 (P=0.0381). Mutations in epigenetic regulator, ASXL1, TET2, TET3, KDM1A and MSH6 were found in 25% of patients. TET2 or TET3, AKT1 and RUNX1 were mutated in one patient each. ASXL1 was mutated within exon 12 in three cases PMID: 28452984
16. TET2, ASXL1, IDH1, and IDH2 Single Nucleotide Polymorphisms in Turkish Patients with Chronic Myeloproliferative Neoplasms. PMID: 28218607
17. Here we report that retinoic acid (RA) or retinol (vitamin A) and ascorbate (vitamin C) act as modulators of TET levels and activity. RA or retinol enhances 5hmC production in naive embryonic stem cells by activation of TET2 and TET3 transcription, whereas ascorbate potentiates TET activity and 5hmC production through enhanced Fe(2+) recycling, and not as a cofactor as reported previously PMID: 27729528
18. identified a novel case of a donor-derived myelodysplastic syndrome in an HSCT recipient that is consistent with clonal evolution of TET2-mutated clonal hematopoiesis of indeterminate potential (CHIP) PMID: 27497531
19. TET2 in African Americans was associated with aggressive prostate cancer, with 24.4% of cases harboring a rare deleterious variant compared with 9.6% of controls PMID: 27486019
20. Therefore, chemical hypoxia not only causes overexpression of TET1 and TET2 but also could gradually do promoter demethylation of same genes PMID: 28252217
21. Overexpression of the wild-type TET1/2/3 3'UTR caused a significant increase in EZH2 expression and tumor growth, whereas the mutation in miR-26-binding sites abolished this effect. PMID: 28923852
22. Tet methylcytosine dioxygenase 2 (TET2) mutations can be detected in human MPhis cultured from MDS/CMML patient samples. PMID: 28826859
23. Concurrent STAT3, DNMT3A, and TET2 mutations in T-LGL leukemia with molecularly distinct clonal hematopoiesis of indeterminate potential PMID: 27761930
24. Multivariate analysis showed that KIT-AL and TET2 mutations were associated with inferior LFS, whereas age 40 years and marrow blast 70% were associated with inferior OS. PMID: 27391574
25. TET2- and TDG-mediated changes are required for the acquisition of distinct histone modifications in divergent terminal differentiation of myeloid cells. PMID: 28973458
26. alterations in DNMT3A and TET2 may be associated with acute myeloid leukemia prognosis PMID: 28992762
27. Mutation in the TET2 gene is associated with acute myeloid leukemia patients with lympho-myeloid clonal hematopoiesis. PMID: 27881874
28. TET2-mutated haematopoietic precursor cells in Angioimmunoblastic T-cell lymphomas (AITLs) patients not only give rise to the T-cell lymphoma but also generate a large population of mutated mature B cells. PMID: 28337768
29. TET2 and RhoA mutations cooperatively disrupt T cell homeostasis PMID: 28691928
30. TET2 removes aberrant DNA methylation during oxidative stress through interaction with DNA methyltransferases in a "Yin-Yang" complex targeted to chromatin and enhanced by p300 mediated TET2 acetylation. PMID: 28107650
31. we show that the TET2 expression and 5hmC abundance are significantly altered in the umbilical veins of GDM and preeclampsia.The alteration of TET expression, 5hmC levels and 5hmC-mediated transposon activity was further confirmed using established hypoxia cell culture model, which could be rescued by vitamin C, a known activator of TET proteins PMID: 27005421
32. Because the DNA hypomethylation might be a result of TET dioxygenase activity, the study examined expression of TET1-3 enzymes and the level of their product, 5-hydroxymethylcytosine (5hmC), in a panel of histologically characterized seminomas and non-seminomatous germ cell tumors. The study found highly increased expression of TET1 dioxygenase in most seminomas and strong TET1 staining in seminoma cells. PMID: 28218476
33. this study shows that Tet2 expression is increased in intratumoral myeloid cells in melanoma patients PMID: 28813659
34. hypermethylation of the MEG3 promoter in AML may result from decreased TET2 activity. These data provide insight into the molecular mechanisms underlying AML development and progression PMID: 28407691
35. Our findings suggest that TET2 mutations have no prognosis impact on overall survival of patients with myelodysplastic syndromes PMID: 28521175
36. ANRIL knockdown blocks the effects of TET2 on gastric cancer cell proliferation and colony formation. PMID: 27027260
37. indicate that AID and TET2 share common effects on myeloid and erythroid lineage differentiation, however, their role is nonredundant in regulating HSC self-renewal and in myeloid transformation. PMID: 28077417
38. The prevalence of TET2 mutations in children with acute myeloid leukemia (AML) compared with adults with AML was lower and less complex. Patients with polymorphism I1762V had an increased 10-year survival rate compared with patients without I1762V. PMID: 26414667
39. Somatic mutations driving clonal hematopoiesis occur mainly in DNMT3A and TET2 and have no significant impact on hematological phenotypes. There is a familial predisposition to acquire TET2 mutation. PMID: 28655780
40. findings have identified distinct roles for TET2 and TET3 in human erythropoiesis, and provide new insights into their role in regulating human erythroid differentiation at distinct stages of development. PMID: 28167661
41. The levels of alpha-KG, TET2 and MMP-9 were significantly increased in diabetic wound compared with nondiabetic wound PMID: 26921880
42. TET2E2S and FLT3-ITD, but not age or NPM1 mutation status were independent prognostic factors for DFS and event-free survival (EFS) in cytogenetically normal acute myelogenous leukemia , while TET2E2S was the sole prognostic factor that we identified for overall survival (OS). PMID: 28167452
43. this study demonstrates the critical role of TET proteins in regulating the crosstalk between two key epigenetic mechanisms. PMID: 27288448
44. TET2 is turned off in normal and malignant germinal center (GC) B cells but expressed in other B cell types. Thus, restricted TET2 expression in GC cells may promote type I Epstein-Barr virus latency. PMID: 28003489
45. Data show that tet oncogene family member 2 (TET2) cysteine-rich (CR) domain mutations disrupt the recognition of histone H3 lysine 36 (H3K36) methylation, its cellular localization, and enzyme activity. PMID: 28130413
46. The data suggest that TET2 activity and the levels of 5-hydroxymethylcytosine and its derivatives should be tightly controlled to avoid genetic and chromosomal instabilities. PMID: 27289557
47. The TET2 active site is shaped to enable higher-order oxidation and provide the first TET variants that could be used to probe the biological functions of 5-methylcytosine separately from 5-formylcytosine and5-carboxylcytosine. PMID: 27918559
48. Our findings provide evidence suggesting that nestin regulation is negatively controlled epigenetically by TET2 in melanoma PMID: 27102770
49. Deregulated BCL6 expression caused by hypermethylation and TET2 mutations may result in skewed follicular helper T cell differentiation and eventually contribute to angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma development in patients PMID: 27921272
50. Our results confirmed that TET2 is frequently mutated in Taiwanese patients with chronic myelomonocytic leukemia PMID: 27418193

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HGNC: 25941

OMIM: 263300

KEGG: hsa:54790

STRING: 9606.ENSP00000369351

UniGene: Hs.367639