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TFB2M Antibody, FITC conjugated

  • 中文名稱：
    TFB2M兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA867154LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TFB2M Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TFB2M
  • 別名：
    N''-adenosyl(rRNA) dimethyltransferase 2 antibody; S adenosylmethionine 6 N', N' adenosyl(rRNA) dimethyltransferase 2 antibody; Dimethyladenosine transferase 2 antibody; dimethyladenosine transferase 2 mitochondrial antibody; FLJ22661 antibody; FLJ23182 antibody; h mtTFB antibody; h mtTFB2 antibody; h-mtTFB antibody; h-mtTFB2 antibody; HCV NS5A transactivated protein 5 antibody; HCV NS5A-transactivated protein 5 antibody; hepatitis C virus NS5A transactivated protein 5 antibody; Hepatitis C virus NS5A-transactivated protein 5 antibody; Hkp1 antibody; hTFB2M antibody; Mitochondrial 12S rRNA dimethylase 2 antibody; mitochondrial antibody; Mitochondrial dimethyladenosine transferase 2 antibody; Mitochondrial transcription factor B2 antibody; mtTFB antibody; mtTFB2 antibody; NS5ATP5 antibody; S-adenosylmethionine-6-N'' antibody; TFB2M antibody; TFB2M_HUMAN antibody; Transcription Factor B2 antibody; Transcription factor B2 mitochondrial antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Dimethyladenosine transferase 2, mitochondrial protein (30-108AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (Probable). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Stimulates transcription independently of the methyltransferase activity.
  • 基因功能參考文獻：
    1. Study reports crystal structures of human mitochondrial transcription initiation complexes assembled on both light and heavy strand promoters. The structures reveal how transcription factors TFAM and TFB2M assist mitochondrial RNA polymerase to achieve promoter-dependent initiation. PMID: 29149603
    2. demonstrate that a complex composed of TFAM and POLRMT was readily formed at the promoter but alone was insufficient for promoter melting, which only occurred when TFB2M joined the complex PMID: 28028173
    3. The results reveal the organization of TFAM, POLRMT and TFB2M around the light-strand promoter and represent the first structural characterization of the entire mitochondrial transcriptional initiation complex. PMID: 24413562
    4. only two essential initiation factors, TFAM and TFB2M, and two promoters, LSP and HSP1, are required to drive transcription of the mitochondrial genome PMID: 20410300
    5. The mRNA levels of TFB1M and TFB2M are influenced by endurance training PMID: 19681768
    6. This transcription factor activates transcription of human mitochondrial DNA. PMID: 12068295
    7. Distinct, but possibly coordinated functions of mtTFB1 and mtTFB2 in mitochondrial gene expression and biogenesis. PMID: 17557812
    8. This study suggested that DNA variants in TFB2M did not contribute to the risk for parkinson disease. PMID: 18980857
    9. determined the variation in the TFAM, TFB1M, and TFB2M genes in cardiac hypertrophy PMID: 19096125
    10. rRNA methyltransferase activity is necessary for induction of mitochondrial biogenesis by TFB1M, but not TFB2M. PMID: 19417006
    11. Promoter-independent DNA conformation-dependent transcription required TFB2M. PMID: 19624753

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  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, rRNA adenine N(6)-methyltransferase family, KsgA subfamily
  • 組織特異性：
    Ubiquitously expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18559

    OMIM: 607055

    KEGG: hsa:64216

    STRING: 9606.ENSP00000355471

    UniGene: Hs.7395